Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K11_HUMAN
Description:mitogen-activated protein kinase kinase kinase 11 [Source:HGNC Symbol;Acc:6850]
Location:chr11 q13.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T755PGTPGtPRSPPPhosphoSitePlus; HPRD
S815DPFWDsPPANPPhosphoSitePlus; HPRD; SysPTM
S727QRSAKsPRREEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S674RERGEsPTTPPAKT_groupRegPhos
T677GESPTtPPTPTPhosphoSitePlus
S770SRPRPsPLRSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S35GRPEGsPKAAGPhosphoSitePlus; HPRD; SysPTM
T277REWHKtTQMSAautocatalysisRegPhos
S793PSPLPsPQPAPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S281KTTQMsAAGTYHPK1(MAP4K1RegPhos
S19GSWNGsGSGGGHPRD
S674RERGEsPTTPPAKT1HPRD; RegPhos
T277REWHKtTQMSAPkinase_TyrPhosphoSitePlus
S281KTTQMsAAGTYPkinase_TyrPhosphoSitePlus
S724PVGQRsAKSPRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S281KTTQMsAAGTYMAP3K11phosphoELM
S524VGPGDsPTFPRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T702CFSLKtPDSPPPhosphoSitePlus; HPRD; phosphoELM
S569WAWGPsSPKPGHPRD
T277REWHKtTQMSAMLK3RegPhos
S281KTTQMsAAGTYHPK1RegPhos
S758PGTPRsPPLGLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S674RERGEsPTTPPPKB_groupphosphoELM
S746PPPGTsRSAPGHPRD; RegPhos
T738EPRGGtVSPPPPhosphoSitePlus; HPRD; RegPhos
S281KTTQMsAAGTYMAP4K1HPRD; phosphoELM
S693TEPPPsPLICFPhosphoSitePlus
S556RLEDSsNGERRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S765PLGLIsRPRPSHPRD
S555RRLEDsSNGERPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S507ITVQAsPGLDRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T277REWHKtTQMSAMLK3(MAP3K11RegPhos
S394RDSFHsMQEGWDUF4393PhosphoSitePlus
S740RGGTVsPPPGTPhosphoSitePlus; HPRD; RegPhos; SysPTM
S674RERGEsPTTPPPhosphoSitePlus
S11SLFLKsPLGSWPhosphoSitePlus; HPRD
T708PDSPPtPAPLLPhosphoSitePlus; HPRD; phosphoELM
S748PGTSRsAPGTPPhosphoSitePlus; HPRD; SysPTM
T277REWHKtTQMSAMAP3K11HPRD; phosphoELM
S281KTTQMsAAGTYMLK3(MAP3K11RegPhos
S654TALLAsLGLGRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S705LKTPDsPPTPAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S548AWGRQsPRRLEPhosphoSitePlus; HPRD; SysPTM
S281KTTQMsAAGTYautocatalysisRegPhos
S789AGPRPsPLPSPPhosphoSitePlus; HPRD; phosphoELM
T752RSAPGtPGTPRPhosphoSitePlus; HPRD
S493GGERIsMPLDFPhosphoSitePlus; HPRD; SysPTM

Dephosphorylation site
M3K11_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000309597R659HBIOMARTNeoplasms by Histologic Type21930507, 21930502

Differential expressed protein
M3K11_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K11_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K11_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
M3K11_HUMANMP2K7_HUMANkinase -> substrateKEGG
M3K11_HUMANMP2K4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
M4K1_HUMANM3K11_HUMANkinase -> substrateKEGG; HPRD; RegPhos
M3K11_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANM3K11_HUMANkinase -> substrateRegPhos
AKT1_HUMANM3K11_HUMANkinase -> substrateHPRD; RegPhos
M3K11_HUMANM3K11_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046777protein autophosphorylationIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0042803protein homodimerization activityIPImolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0000187activation of MAPK activityIMPbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0046328regulation of JNK cascadeIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0031435mitogen-activated protein kinase kinase kinase binIPImolecular_function
GO:0007256activation of JNKK activityIEAbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0043507positive regulation of JUN kinase activityIMPbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0008283cell proliferationIMPbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0007017microtubule-based processIMPbiological_process
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0031434mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004706JUN kinase kinase kinase activityIEAmolecular_function
GO:0046330positive regulation of JNK cascadeIMPbiological_process
GO:0000080G1 phase of mitotic cell cycleIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0008219cell deathIEAbiological_process
GO:0007257activation of JUN kinase activityIMPbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0048365Rac GTPase bindingIEAmolecular_function
GO:0005874microtubuleIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0007254JNK cascadeIEAbiological_process


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