| UniProt/SwissProt ID: | M3K8_HUMAN |
| Description: | mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:6860] |
| Location: | chr10 p11.23 |
| Node attribute: | substrate; kinase; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S62 | DERSKsLLLSG | PhosphoSitePlus | |
| T290 | KDLRGtEIYMS | Pkinase | PhosphoSitePlus |
| Y136 | PWKLTyRNIGS | PhosphoSitePlus | |
| S400 | QPRCQsLDSAL | PhosphoSitePlus | |
| S141 | YRNIGsDFIPR | HPRD; phosphoELM; SysPTM | |
| S334 | KRYPRsAYPSY | Pkinase | PhosphoSitePlus |
| S400 | QPRCQsLDSAL | AKT1 | HPRD; RegPhos |
| S125 | RYQIDsDVLLI | PhosphoSitePlus | |
| S400 | QPRCQsLDSAL | PKB_group | phosphoELM |
| S413 | RKRLLsRKELE | phosphoELM; RegPhos | |
| S141 | YRNIGsDFIPR | Pkinase | PhosphoSitePlus; SysPTM |
| T290 | KDLRGtEIYMS | phosphoELM; RegPhos | |
| S413 | RKRLLsRKELE | AKT1 | HPRD; RegPhos |
| S368 | ELIEAsLERNP | Pkinase; HTH_8 | PhosphoSitePlus |
| S400 | QPRCQsLDSAL | AKT_group | RegPhos |
| Y153 | AFGKVyLAQDI | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| M3K8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263056 | A387T | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000263056 | Uterine Cancer | Normal vs. Cancer | cell line | Up | 6.2 | 15838902 |
| Hyperphosphorylation site |
| M3K8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| M3K8_HUMAN | M3K14_HUMAN | kinase -> substrate | KEGG; HPRD; RegPhos; Robert H Newman (2013) |
| M3K8_HUMAN | MP2K1_HUMAN | kinase -> substrate | RegPhos; NetPath; Robert H Newman (2013) |
| M3K8_HUMAN | MP2K2_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| M3K8_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K8_HUMAN | NDF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | M3K8_HUMAN | kinase -> substrate | RegPhos |
| M3K8_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT3_HUMAN | M3K8_HUMAN | kinase -> substrate | KEGG |
| M3K8_HUMAN | CRY1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| EPHA3_HUMAN | M3K8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK09_HUMAN | M3K8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K8_HUMAN | UHMK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K8_HUMAN | IKKA_HUMAN | kinase -> substrate | KEGG |
| M3K8_HUMAN | CHK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | M3K8_HUMAN | kinase -> substrate | RegPhos |
| M3K8_HUMAN | NFKB1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04660 | T cell receptor signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |