Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K8_HUMAN
Description:mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:6860]
Location:chr10 p11.23
Node attribute:substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S62DERSKsLLLSGPhosphoSitePlus
T290KDLRGtEIYMSPkinasePhosphoSitePlus
Y136PWKLTyRNIGSPhosphoSitePlus
S400QPRCQsLDSALPhosphoSitePlus
S141YRNIGsDFIPRHPRD; phosphoELM; SysPTM
S334KRYPRsAYPSYPkinasePhosphoSitePlus
S400QPRCQsLDSALAKT1HPRD; RegPhos
S125RYQIDsDVLLIPhosphoSitePlus
S400QPRCQsLDSALPKB_groupphosphoELM
S413RKRLLsRKELEphosphoELM; RegPhos
S141YRNIGsDFIPRPkinasePhosphoSitePlus; SysPTM
T290KDLRGtEIYMSphosphoELM; RegPhos
S413RKRLLsRKELEAKT1HPRD; RegPhos
S368ELIEAsLERNPPkinase; HTH_8PhosphoSitePlus
S400QPRCQsLDSALAKT_groupRegPhos
Y153AFGKVyLAQDIPkinasePhosphoSitePlus

Dephosphorylation site
M3K8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263056A387TBIOMARTNeoplasms by Histologic Type21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000263056Uterine CancerNormal vs. Cancercell lineUp6.215838902

Hyperphosphorylation site
M3K8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K8_HUMANM3K14_HUMANkinase -> substrateKEGG; HPRD; RegPhos; Robert H Newman (2013)
M3K8_HUMANMP2K1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
M3K8_HUMANMP2K2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
M3K8_HUMANGRK5_HUMANkinase -> substrateRobert H Newman (2013)
M3K8_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANM3K8_HUMANkinase -> substrateRegPhos
M3K8_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
AKT3_HUMANM3K8_HUMANkinase -> substrateKEGG
M3K8_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANM3K8_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANM3K8_HUMANkinase -> substrateRobert H Newman (2013)
M3K8_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
M3K8_HUMANIKKA_HUMANkinase -> substrateKEGG
M3K8_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANM3K8_HUMANkinase -> substrateRegPhos
M3K8_HUMANNFKB1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0031295T cell costimulationTASbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function


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