Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PAIRB_HUMAN
Description:SERPINE1 mRNA binding protein 1 [Source:HGNC Symbol;Acc:17860]
Location:chr1 p31.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S199DRHSGsDRSSFHPRD
S234DELTEsPKYIQHABP4_PAI-RBP1PhosphoSitePlus; SysPTM
S317AHAEDsVMDHHHPRD
S377RTDKSsASAPDHPRD
S243IQKQIsYNYSDHABP4_PAI-RBP1PhosphoSitePlus
Y246QISYNySDLDQHABP4_PAI-RBP1PhosphoSitePlus
T382NRGSRtDKSSAHPRD
T232VKDELtESPKYHABP4_PAI-RBP1PhosphoSitePlus
Y244QKQISyNYSDLHABP4_PAI-RBP1PhosphoSitePlus
S205DRSSFsHYSGLHABP4_PAI-RBP1PhosphoSitePlus
S203GSDRSsFSHYSHPRD; phosphoELM; SysPTM
T226VKDELtESPKYHPRD
S324LHKSKsEEAHAHPRD
S353ANDITsQLEINPhosphoSitePlus
S370SRTDKsSASAPHPRD
S213DKRGGsGSHNWHPRD
S85NPLPPsVGVVDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S246SDLDQsNVTEEHPRD
S371RTDKSsASAPDHPRD
S241ISYNYsDLDQSHPRD
S221RGGSGsHNWGTHABP4_PAI-RBP1PhosphoSitePlus; SysPTM
Y231TESPKyIQKQIHPRD
S237TDLDQsNVTEEHPRD
S247ISYNYsDLDQSHPRD; SysPTM
S394DKSSAsAPDVDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S323AHAEDsVMDHHHPRD
Y237TESPKyIQKQIHPRD; phosphoELM
S53GPGAKsAAQAAPhosphoSitePlus; HPRD
S392RTDKSsASAPDPhosphoSitePlus; HPRD; phosphoELM
T388NRGSRtDKSSAHPRD
S63AAQTNsNAAGKPhosphoSitePlus
S373DKSSAsAPDVDHPRD
S322FVLHKsKSEEAHPRD
S199DRHSGsDRSGLHPRD
S330LHKSKsEEAHAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T234DQSNVtEETPEHPRD
S332AHAEDsVMDHHHPRD
S203GSDRSsFSHYSHABP4_PAI-RBP1PhosphoSitePlus; SysPTM
S231TDLDQsNVTEEHPRD
S391SRTDKsSASAPHPRD; phosphoELM
S307FVLHKsKSEEAHPRD
T367NRGSRtDKSSAHPRD
S315LHKSKsEEAHAHPRD
S25LFDDEsDPFEVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S328FVLHKsKSEEAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S309LHKSKsEEAHAHPRD
T373NRGSRtDKSSAHPRD
S202SGSDRsSFSHYHABP4_PAI-RBP1PhosphoSitePlus
S379DKSSAsAPDVDHPRD
T61QAAAQtNSNAAPhosphoSitePlus; HPRD; phosphoELM
S388DKSSAsAPDVDHPRD
S228DELTEsPKYIQHPRD
S313FVLHKsKSEEAHPRD
S202SGSDRsSFSHYHPRD; phosphoELM
T232VKDELtESPKYHPRD; phosphoELM
S197EFDRHsGSDRSHABP4_PAI-RBP1PhosphoSitePlus
Y237TESPKyIQKQIHABP4_PAI-RBP1PhosphoSitePlus
S385SRTDKsSASAPHPRD
S376SRTDKsSASAPHPRD
S197EFDRHsGSDRSHPRD; phosphoELM
S219DKRGGsGSHNWHPRD
S338AHAEDsVMDHHPhosphoSitePlus; HPRD; phosphoELM
T95DKKEEtQPPVAPhosphoSitePlus
S247ISYNYsDLDQSHABP4_PAI-RBP1PhosphoSitePlus; SysPTM
S386RTDKSsASAPDHPRD
T240DQSNVtEETPEHPRD
S208SFSHYsGLKHEHABP4_PAI-RBP1PhosphoSitePlus
Y207SSFSHySGLKHHABP4_PAI-RBP1PhosphoSitePlus; SysPTM
T255DQSNVtEETPEphosphoELM
S215RGGSGsHNWGTHPRD
S221RGGSGsHNWGTHPRD; phosphoELM; SysPTM
S252SDLDQsNVTEEHPRD; phosphoELM
S234DELTEsPKYIQHPRD; phosphoELM; SysPTM

Dephosphorylation site
PAIRB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360034K236NCOSMICHead and Neck Cancer21798893
ENSP00000360034E35DCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000360034Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.220804217

Hyperphosphorylation site
PAIRB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KKCC1_HUMANPAIRB_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANPAIRB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PAIRB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0043488regulation of mRNA stabilityNASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0003730mRNA 3'-UTR bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component


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