Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KCC4_HUMAN
Description:calcium/calmodulin-dependent protein kinase IV [Source:HGNC Symbol;Acc:1464]
Location:chr5 q22.1
Node attribute:substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T200QVLMKtVCGTPCaMKK2RegPhos
T200QVLMKtVCGTPCaMKK1RegPhos
S341SSRLGsASSSHCAMK4HPRD
S12PSCSAsSCSSVPhosphoSitePlus
S356ESHKAsRDPSPPhosphoSitePlus; HPRD
T200QVLMKtVCGTPCaM-KI_alphaphosphoELM
S343RLGSAsSSHGSPhosphoSitePlus
S360ASRDPsPIQDGCAMK4HPRD
S12PSCSAsSCSSVautocatalysisRegPhos
S336KAVVAsSRLGSautocatalysisRegPhos
T200QVLMKtVCGTPCaMK1aRegPhos
S13SCSASsCSSVTautocatalysisRegPhos
Y32SLVPDyWIDGSPhosphoSitePlus
T200QVLMKtVCGTPCAMKK2HPRD
S341SSRLGsASSSHPhosphoSitePlus; phosphoELM; RegPhos
T200QVLMKtVCGTPPkinasePhosphoSitePlus
T200QVLMKtVCGTPCAMKK1HPRD
S360ASRDPsPIQDGPhosphoSitePlus; phosphoELM; RegPhos
S344LGSASsSHGSIPhosphoSitePlus
S189ADFGLsKIVEHPkinasePhosphoSitePlus
S13SCSASsCSSVTPhosphoSitePlus
T200QVLMKtVCGTPRegPhos

Dephosphorylation site
KCC4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282356Q147KBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000282356K146ETCGAOvarian Cancer21720365, 18772890
ENSP00000282356E150GGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000282356I469MHPINon-small cell lung carcinoma17344846
ENSP00000282356*474GCOSMICOvarian Cancer21720365
ENSP00000282356A390VTCGAOvarian Cancer21720365, 18772890
ENSP00000422634*474GCOSMICOvarian Cancer21720365
ENSP00000282356I469MGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000282356A329ETCGAOvarian Cancer21720365, 18772890
ENSP00000422634A329ETCGAOvarian Cancer21720365, 18772890
ENSP00000422634A390VTCGAOvarian Cancer21720365, 18772890
ENSP00000422634K146ETCGAOvarian Cancer21720365, 18772890

Differential expressed protein
KCC4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KCC4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC4_HUMANNOS1_HUMANkinase -> substrateHPRD
KCC4_HUMANKCND2_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANRNPS1_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANVPS72_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANKCC1A_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANK1C18_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANGRIA1_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANDHPR_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANDLG1_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANTY3H_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANPPLA_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANCOF2_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANHDAC4_HUMANkinase -> substrateHPRD
KCC4_HUMANFLNA_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANCEBPB_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANCREB1_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANAT2A2_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANK2C8_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANKCC4_HUMANkinase -> substrateHPRD
KCC4_HUMANGFAP_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANPP14A_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANPLCB3_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANADCY3_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANKCC4_HUMANkinase -> substrateHPRD
KCC4_HUMANPEA15_HUMANkinase -> substrateRobert H Newman (2013)
KKCC1_HUMANKCC4_HUMANkinase -> substrateHPRD
ZAGL2_HUMANKCC4_HUMANkinase -> substrateRegPhos
KCC4_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANCBP_HUMANkinase -> substrateHPRD
KCC4_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANSPRE_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANPLCG1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04720Long-term potentiation
hsa05031Amphetamine addiction
hsa04380Osteoclast differentiation
hsa05034Alcoholism
hsa04725Cholinergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationTASbiological_process
GO:0043011myeloid dendritic cell differentiationIMPbiological_process
GO:0006913nucleocytoplasmic transportIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0033081regulation of T cell differentiation in thymusTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005634nucleusIEAcellular_component
GO:0005516calmodulin bindingIEAmolecular_function
GO:0045670regulation of osteoclast differentiationTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0004683calmodulin-dependent protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0007270neuron-neuron synaptic transmissionIEAbiological_process
GO:0046827positive regulation of protein export from nucleusIEAbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0007616long-term memoryIGIbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process


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