Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KKCC2_HUMAN
Description:calcium/calmodulin-dependent protein kinase kinase 2, beta [Source:HGNC Symbol;Acc:1470]
Location:chr12 q24.31
Node attribute:kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T350SNTVGtPAFMAPkinasePhosphoSitePlus
Y234PIEQVyQEIAIPkinasePhosphoSitePlus
S129PSLPYsPVSSPPhosphoSitePlus; HPRD; phosphoELM
S511EERSLsAPGNLDAPK1phosphoELM
S132PYSPVsSPQSSPhosphoSitePlus; HPRD
Y190ENDNTyYAMKVPkinasePhosphoSitePlus
S452MIRKRsFGNPFHPRD
S466RREERsLSAPGHPRD
Y183VVKLAyNENDNPkinasePhosphoSitePlus
S100SGRKLsLQERSPhosphoSitePlus
Y128CPSLPySPVSSPhosphoSitePlus; HPRD
S511EERSLsAPGNLPhosphoSitePlus; HPRD
S133YSPVSsPQSSPPhosphoSitePlus; HPRD; phosphoELM
S522LTKQGsEDNLQHPRD
S137SSPQSsPRLPRPhosphoSitePlus
S136VSSPQsSPRLPPhosphoSitePlus; HPRD; phosphoELM
S468EERSLsAPGNLHPRD
S495MIRKRsFGNPFPhosphoSitePlus; HPRD
T145LPRRPtVESHHPhosphoSitePlus
S511EERSLsAPGNLDAPK_groupphosphoELM
S479LTKQGsEDNLQHPRD
S509RREERsLSAPGPhosphoSitePlus; HPRD

Dephosphorylation site
KKCC2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000312741P127LGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000312741A182TGreenman2007Intestines Cancer17344846, 18428421
ENSP00000312741A182THPIColorectal Cancer17344846

Differential expressed protein
KKCC2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KKCC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KKCC2_HUMANKCC1A_HUMANkinase -> substrateHPRD
KKCC2_HUMANAAKG2_HUMANkinase -> substrateKEGG
KKCC2_HUMANPK3C3_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANEFTU_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANRAP1A_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANCDK16_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KKCC2_HUMANKCC4_HUMANkinase -> substrateHPRD
KKCC2_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
ADR1_HUMANKKCC2_HUMANotherKEGG
OBRG_HUMANKKCC2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04920Adipocytokine signaling pathway
hsa05034Alcoholism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0000165MAPK cascadeTASbiological_process
GO:0045859regulation of protein kinase activityTASbiological_process
GO:0005622intracellularTAScellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0019722calcium-mediated signalingTASbiological_process
GO:0004683calmodulin-dependent protein kinase activityIEAmolecular_function
GO:0005509calcium ion bindingIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005516calmodulin bindingTASmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenTASbiological_process


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