Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPCZ_HUMAN
Description:protein kinase C, zeta [Source:HGNC Symbol;Acc:9412]
Location:chr1 p36.33
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T560EPVQLtPDDEDphosphoELM; RegPhos; SysPTM
S223SRKHDsIKDDSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T560EPVQLtPDDEDPRKCZHPRD; SysPTM
T560EPVQLtPDDEDPKC_zetaphosphoELM; SysPTM
T227GDTTStFCGTPPDPK1HPRD
S40SRKHDsIKDDSHPRD
S190DSVMPsQEPPVPhosphoSitePlus
T560EPVQLtPDDEDPKCzRegPhos; SysPTM
T410GDTTStFCGTPPDK-1phosphoELM; SysPTM
S409PGDTTsTFCGTPkinasePhosphoSitePlus
T410GDTTStFCGTPphosphoELM; SysPTM
T560EPVQLtPDDEDPKCz(PKC zetaRegPhos; SysPTM
T377EPVQLtPDDEDPRKCZHPRD
Y417CGTPNyIAPEIPkinasePhosphoSitePlus
T560EPVQLtPDDEDPkinase_CPhosphoSitePlus; SysPTM
Y428LRGEEyGFSVDPkinasePhosphoSitePlus
T410GDTTStFCGTPPkinasePhosphoSitePlus; SysPTM
T410GDTTStFCGTPPDK1RegPhos; SysPTM
T410GDTTStFCGTPPDPK1HPRD; SysPTM

Dephosphorylation site
KPCZ_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000367830D230NBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000367830D251ACOSMICOvarian Cancer21720365
ENSP00000383712D68ATCGAOvarian Cancer21720365, 18772890
ENSP00000383711E391KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000383711D68ATCGAOvarian Cancer21720365, 18772890
ENSP00000383712E391KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000367830S514FSjoblom2006Intestines Cancer16959974
ENSP00000383711R77HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000367830S514FBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000367830R519CHPIColorectal Cancer17344846
ENSP00000383712E25KBIOMARTBreast Cancer21930507, 21930502
ENSP00000367830R519CGreenman2007Intestines Cancer17344846, 18428421
ENSP00000367830R370KCOSMICHead and Neck Cancer21798893
ENSP00000367830R260CCOSMICOvarian Cancer21720365
ENSP00000383711E25KBIOMARTBreast Cancer21930507, 21930502
ENSP00000383712R77HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000367830E208KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
KPCZ_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KPCZ_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCZ_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANNUMB_HUMANkinase -> substrateHPRD
KPCZ_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANJAK1_HUMANkinase -> substrateNetPath
KPCZ_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANGEM_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANADDB_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMAN1433B_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCZ_HUMANADDA_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANAKT3_HUMANkinase -> substrateHPRD
KPCZ_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANKPCZ_HUMANkinase -> substrateHPRD; RegPhos
KPCZ_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANIRS1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANTRIP6_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANBFAR_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANGELS_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANCLAT_HUMANkinase -> substrateHPRD
KPCZ_HUMANKS6B2_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANRAB14_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANPHOS_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANNASP_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANPSN1_HUMANkinase -> substrateHPRD
KPCZ_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANANXA2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKPCZ_HUMANkinase -> substrateRegPhos
KPCZ_HUMANTYDP2_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANANS1A_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANTRAF2_HUMANkinase -> substrateNetPath
KPCZ_HUMANKPCD_HUMANkinase -> substrateHPRD
KPCZ_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANKPCZ_HUMANkinase -> substrateHPRD
KPCZ_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANIKKB_HUMANkinase -> substrateHPRD
KPCZ_HUMANKPCA_HUMANkinase -> substrateHPRD
KPCZ_HUMANKIBRA_HUMANkinase -> substrateHPRD
KPCZ_HUMANARI3A_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANSPAG7_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANPEBP1_HUMANkinase -> substrateHPRD
KPCZ_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANGRM5_HUMANkinase -> substrateHPRD
KPCZ_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANPP14A_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCZ_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANHABP4_HUMANkinase -> substrateHPRD
KPCZ_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANTF65_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
KPCZ_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANLARP1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANDDB1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANCASP9_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCZ_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04930Type II diabetes mellitus
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa04910Insulin signaling pathway
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046627negative regulation of insulin receptor signaling IMPbiological_process
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0031532actin cytoskeleton reorganizationIEAbiological_process
GO:0050806positive regulation of synaptic transmissionIEAbiological_process
GO:0031584activation of phospholipase D activityIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005911cell-cell junctionIDAcellular_component
GO:0015459potassium channel regulator activityIEAmolecular_function
GO:0060081membrane hyperpolarizationIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:2000553positive regulation of T-helper 2 cell cytokine prIEAbiological_process
GO:0004697protein kinase C activityIEAmolecular_function
GO:0004672protein kinase activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0016020membraneTAScellular_component
GO:0060291long-term synaptic potentiationIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:2000463positive regulation of excitatory postsynaptic memIEAbiological_process
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0031252cell leading edgeIEAcellular_component
GO:0045179apical cortexIEAcellular_component
GO:0043560insulin receptor substrate bindingICmolecular_function
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0046326positive regulation of glucose importIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0016477cell migrationIEAbiological_process
GO:007188914-3-3 protein bindingIEAmolecular_function
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0070528protein kinase C signaling cascadeIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:2000664positive regulation of interleukin-5 secretionIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0016363nuclear matrixIEAcellular_component
GO:0005635nuclear envelopeIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:2001181positive regulation of interleukin-10 secretionIEAbiological_process
GO:0001954positive regulation of cell-matrix adhesionIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005768endosomeIEAcellular_component
GO:0051899membrane depolarizationIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:2000667positive regulation of interleukin-13 secretionIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0032148activation of protein kinase B activityIEAbiological_process
GO:0072659protein localization to plasma membraneIEAbiological_process
GO:0005938cell cortexIEAcellular_component
GO:0051222positive regulation of protein transportIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0046628positive regulation of insulin receptor signaling IEAbiological_process
GO:0035748myelin sheath abaxonal regionIEAcellular_component
GO:0047496vesicle transport along microtubuleIEAbiological_process
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0030054cell junctionTAScellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007616long-term memoryIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0030010establishment of cell polarityIEAbiological_process
GO:0050732negative regulation of peptidyl-tyrosine phosphoryIMPbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0034613cellular protein localizationIEAbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045630positive regulation of T-helper 2 cell differentiaIEAbiological_process
GO:0051346negative regulation of hydrolase activityIEAbiological_process
GO:0032753positive regulation of interleukin-4 productionIEAbiological_process
GO:0031333negative regulation of protein complex assemblyIMPbiological_process
GO:0005923tight junctionIEAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0043274phospholipase bindingIEAmolecular_function