Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KIBRA_HUMAN
Description:WW and C2 domain containing 1 [Source:HGNC Symbol;Acc:29435]
Location:chr5 q34
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y788LLSYKyLKKQSPhosphoSitePlus
Y128LAQQEyQQLHAPhosphoSitePlus
Y781RSTRWyNLLSYPhosphoSitePlus
S975MKRPSsVKSLRPhosphoSitePlus
S815STDAVsALLEQPhosphoSitePlus
S255RTDRGsHSDLWPhosphoSitePlus
T527RSLSGtPKSMTPhosphoSitePlus
S539LSPRSsLSSPSPhosphoSitePlus
T895ETNTEtPAPSPPhosphoSitePlus; HPRD; phosphoELM
S975MKRPSsVKSLRPRKCZHPRD
S931RSKTFsPGPQSPhosphoSitePlus; HPRD; phosphoELM
T901PAPSPtVVRPKPhosphoSitePlus
S427QLKSLsSSMQSPhosphoSitePlus
S542RSSLSsPSPPCPhosphoSitePlus
S927STIIRsKTFSPHPRD
S978PSSVKsLRSERPhosphoSitePlus
T923FLRGStIIRSKHPRD
Y938GPQSQyVCRLNPhosphoSitePlus
S241QDLIKsLAMLKPhosphoSitePlus
S978PSSVKsLRSERPRKCZHPRD
S523LQALRsLSGTPPhosphoSitePlus
S947LNRSDsDSSTLPhosphoSitePlus; HPRD; phosphoELM
T929IIRSKtFSPGPPhosphoSitePlus; HPRD; phosphoELM
S899ETPAPsPTVVRPhosphoSitePlus; HPRD; phosphoELM
S922PFLRGsTIIRSHPRD
T912DRRVGtPSQGPPhosphoSitePlus; HPRD; phosphoELM
S945CRLNRsDSDSSPhosphoSitePlus
Y786YNLLSyKYLKKPhosphoSitePlus
T893DKETNtETPAPPhosphoSitePlus

Dephosphorylation site
KIBRA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000427772R989HTCGAOvarian Cancer21720365, 18772890
ENSP00000265293R983HCOSMICOvarian Cancer21720365
ENSP00000265293Q104*COSMICMelanoma21499247

Differential expressed protein
KIBRA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KIBRA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANKIBRA_HUMANkinase -> substrateRegPhos
KPCZ_HUMANKIBRA_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KIBRA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035330regulation of hippo signaling cascadeIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0016477cell migrationIDAbiological_process
GO:0032587ruffle membraneIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005794Golgi apparatusIDAcellular_component
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0016477cell migrationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0030674protein binding, bridgingIEAmolecular_function
GO:0035329hippo signaling cascadeTASbiological_process


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