| UniProt/SwissProt ID: | GEM_HUMAN |
| Description: | GTP binding protein overexpressed in skeletal muscle [Source:HGNC Symbol;Acc:4234] |
| Location: | chr8 q22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S261 | QKRKEsMPRKA | PhosphoSitePlus; HPRD; RegPhos | |
| S23 | QQQRWsIPADG | PhosphoSitePlus | |
| S287 | AFKLKsKSCHD | PhosphoSitePlus | |
| S261 | QKRKEsMPRKA | PKCz(PKC zeta | RegPhos |
| S261 | QKRKEsMPRKA | PKC_zeta | phosphoELM |
| S289 | KLKSKsCHDLS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y255 | ERRLAyQKRKE | PhosphoSitePlus | |
| Dephosphorylation site |
| GEM_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000297596 | R176L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000297596 | V211L | COSMIC | Lung Cancer | 20668451 | ENSP00000379497 | V211L | COSMIC | Lung Cancer | 20668451 | ENSP00000379497 | R176L | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| GEM_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GEM_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCZ_HUMAN | GEM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | GEM_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| GEM_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0015684 | ferrous iron transport | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005525 | GTP binding | IDA | molecular_function |
| GO:0015093 | ferrous iron transmembrane transporter activity | IEA | molecular_function |
| GO:0003924 | GTPase activity | IDA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0009898 | internal side of plasma membrane | IDA | cellular_component |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0005516 | calmodulin binding | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |