Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NUMB_HUMAN
Description:numb homolog (Drosophila) [Source:HGNC Symbol;Acc:8060]
Location:chr14 q24.3
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T377AGHRRtPSEADHPRD
S265LARQGsFRGFPHPRD
S425SSGAAsPGLFQPhosphoSitePlus
S241APSPSsPTSPTPhosphoSitePlus; HPRD; phosphoELM
T425AGHRRtPSEADHPRD
T246SPTSPtSDATTPhosphoSitePlus
S244PSSPTsPTSDAPhosphoSitePlus; HPRD; phosphoELM
S623QRTNPsPTNPFHPRD
S91AVLWVsADGLRPIDPhosphoSitePlus
T102VVDEKtKDLIVPIDPhosphoSitePlus
S379HRRTPsEADRWHPRD
S586QRTNPsPTNPFHPRD
T190SRTTFtREGSFPhosphoSitePlus
T243SPSSPtSPTSDPhosphoSitePlus
S7RRKKPRKCZHPRD
S295FKRQLsLRINEphosphoELM; SysPTM
S575QRTNPsPTNPFHPRD
S634QRTNPsPTNPFPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S295FKRQLsLRINEPRKCZHPRD; SysPTM
T187FDASRtTFTREPhosphoSitePlus
S288LSQKMsPFKRQNumbFPhosphoSitePlus
T102VVDEKtKDLIVAAK1phosphoELM
S390HRRTPsEADRWHPRD
S295FKRQLsLRINENumbFPhosphoSitePlus; SysPTM
S438HRRTPsEADRWPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S276LARQGsFRGFPNumbFPhosphoSitePlus; SysPTM
T436AGHRRtPSEADPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S7NKLRQsFRRKKPhosphoSitePlus
S229TAPSPsSPTSPHPRD
S284FKRQLsLRINEHPRD
S233PSSPTsPTSDAHPRD
T561LVRQQtFPHYEPhosphoSitePlus
T388AGHRRtPSEADHPRD
T251TSDATtSLEMNPhosphoSitePlus
S427HRRTPsEADRWHPRD
S276LARQGsFRGFPHPRD; phosphoELM; SysPTM
S194FTREGsFRVTTPhosphoSitePlus
Y15RKKDVyVPEASPhosphoSitePlus
S238GNTAPsPSSPTPhosphoSitePlus
S20YVPEAsRPHQWPhosphoSitePlus; HPRD
S240TAPSPsSPTSPPhosphoSitePlus; HPRD; phosphoELM
S230APSPSsPTSPTHPRD

Dephosphorylation site
NUMB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000451300P520QCOSMICSkin Cancer21984974
ENSP00000347169T604ACOSMICOvarian Cancer21720365
ENSP00000451300T604ACOSMICOvarian Cancer21720365
ENSP00000451300A621VCOSMICOvarian Cancer21720365
ENSP00000347169A621VCOSMICOvarian Cancer21720365
ENSP00000347169D594VCOSMICSkin Cancer21984974
ENSP00000347169P520QCOSMICSkin Cancer21984974
ENSP00000451300D594VCOSMICSkin Cancer21984974

Differential expressed protein
NUMB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NUMB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCZ_HUMANNUMB_HUMANkinase -> substrateHPRD
NUMB_HUMANNOTC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0021849neuroblast division in subventricular zoneIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045177apical part of cellIEAcellular_component
GO:0008013beta-catenin bindingIEAmolecular_function
GO:0050769positive regulation of neurogenesisIEAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0019897extrinsic to plasma membraneIEAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0034332adherens junction organizationIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0045296cadherin bindingIEAmolecular_function
GO:0030862positive regulation of polarized epithelial cell dIEAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0021670lateral ventricle developmentIEAbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0045294alpha-catenin bindingIEAmolecular_function
GO:0007405neuroblast proliferationIEAbiological_process
GO:0045746negative regulation of Notch signaling pathwayIEAbiological_process
GO:0060487lung epithelial cell differentiationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005769early endosomeIEAcellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23