| UniProt/SwissProt ID: | NUMB_HUMAN |
| Description: | numb homolog (Drosophila) [Source:HGNC Symbol;Acc:8060] |
| Location: | chr14 q24.3 |
| Node attribute: | substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T377 | AGHRRtPSEAD | HPRD | |
| S265 | LARQGsFRGFP | HPRD | |
| S425 | SSGAAsPGLFQ | PhosphoSitePlus | |
| S241 | APSPSsPTSPT | PhosphoSitePlus; HPRD; phosphoELM | |
| T425 | AGHRRtPSEAD | HPRD | |
| T246 | SPTSPtSDATT | PhosphoSitePlus | |
| S244 | PSSPTsPTSDA | PhosphoSitePlus; HPRD; phosphoELM | |
| S623 | QRTNPsPTNPF | HPRD | |
| S91 | AVLWVsADGLR | PID | PhosphoSitePlus |
| T102 | VVDEKtKDLIV | PID | PhosphoSitePlus |
| S379 | HRRTPsEADRW | HPRD | |
| S586 | QRTNPsPTNPF | HPRD | |
| T190 | SRTTFtREGSF | PhosphoSitePlus | |
| T243 | SPSSPtSPTSD | PhosphoSitePlus | |
| S7 | RRKK | PRKCZ | HPRD |
| S295 | FKRQLsLRINE | phosphoELM; SysPTM | |
| S575 | QRTNPsPTNPF | HPRD | |
| S634 | QRTNPsPTNPF | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S295 | FKRQLsLRINE | PRKCZ | HPRD; SysPTM |
| T187 | FDASRtTFTRE | PhosphoSitePlus | |
| S288 | LSQKMsPFKRQ | NumbF | PhosphoSitePlus |
| T102 | VVDEKtKDLIV | AAK1 | phosphoELM |
| S390 | HRRTPsEADRW | HPRD | |
| S295 | FKRQLsLRINE | NumbF | PhosphoSitePlus; SysPTM |
| S438 | HRRTPsEADRW | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S276 | LARQGsFRGFP | NumbF | PhosphoSitePlus; SysPTM |
| T436 | AGHRRtPSEAD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S7 | NKLRQsFRRKK | PhosphoSitePlus | |
| S229 | TAPSPsSPTSP | HPRD | |
| S284 | FKRQLsLRINE | HPRD | |
| S233 | PSSPTsPTSDA | HPRD | |
| T561 | LVRQQtFPHYE | PhosphoSitePlus | |
| T388 | AGHRRtPSEAD | HPRD | |
| T251 | TSDATtSLEMN | PhosphoSitePlus | |
| S427 | HRRTPsEADRW | HPRD | |
| S276 | LARQGsFRGFP | HPRD; phosphoELM; SysPTM | |
| S194 | FTREGsFRVTT | PhosphoSitePlus | |
| Y15 | RKKDVyVPEAS | PhosphoSitePlus | |
| S238 | GNTAPsPSSPT | PhosphoSitePlus | |
| S20 | YVPEAsRPHQW | PhosphoSitePlus; HPRD | |
| S240 | TAPSPsSPTSP | PhosphoSitePlus; HPRD; phosphoELM | |
| S230 | APSPSsPTSPT | HPRD | |
| Dephosphorylation site |
| NUMB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000451300 | P520Q | COSMIC | Skin Cancer | 21984974 | ENSP00000347169 | T604A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000451300 | T604A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000451300 | A621V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000347169 | A621V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000347169 | D594V | COSMIC | Skin Cancer | 21984974 | ENSP00000347169 | P520Q | COSMIC | Skin Cancer | 21984974 | ENSP00000451300 | D594V | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| NUMB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NUMB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCZ_HUMAN | NUMB_HUMAN | kinase -> substrate | HPRD |
| NUMB_HUMAN | NOTC1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04330 | Notch signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0021849 | neuroblast division in subventricular zone | IEA | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0045177 | apical part of cell | IEA | cellular_component |
| GO:0008013 | beta-catenin binding | IEA | molecular_function |
| GO:0050769 | positive regulation of neurogenesis | IEA | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0019897 | extrinsic to plasma membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0034332 | adherens junction organization | IEA | biological_process |
| GO:0030900 | forebrain development | IEA | biological_process |
| GO:0045296 | cadherin binding | IEA | molecular_function |
| GO:0030862 | positive regulation of polarized epithelial cell d | IEA | biological_process |
| GO:0007399 | nervous system development | IEA | biological_process |
| GO:0021670 | lateral ventricle development | IEA | biological_process |
| GO:0007409 | axonogenesis | IEA | biological_process |
| GO:0016323 | basolateral plasma membrane | IEA | cellular_component |
| GO:0045294 | alpha-catenin binding | IEA | molecular_function |
| GO:0007405 | neuroblast proliferation | IEA | biological_process |
| GO:0045746 | negative regulation of Notch signaling pathway | IEA | biological_process |
| GO:0060487 | lung epithelial cell differentiation | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005769 | early endosome | IEA | cellular_component |