Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ULK3_HUMAN
Description:unc-51-like kinase 3 (C. elegans) [Source:HGNC Symbol;Acc:19703]
Location:chr15 q24.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S176HVLRGsPLYMAPkinasePhosphoSitePlus
S176HVLRGsPLYMAHPRD
S165FAQHMsPWDEKHPRD
S219ASRSFsELEEKPkinasePhosphoSitePlus
S300DQEGDsAAALSMITPhosphoSitePlus
S350KAIVSsSNQALPhosphoSitePlus
S384ALEVAsAAMAKMITPhosphoSitePlus
S464EGLSEsVRSSCPhosphoSitePlus
S165FAQHMsPWDEKPkinasePhosphoSitePlus

Dephosphorylation site
ULK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000400312V75GBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
ULK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ULK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ULK3_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
MTOR_HUMANULK3_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04140Regulation of autophagy
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000407pre-autophagosomal structureTAScellular_component
GO:0046777protein autophosphorylationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0045879negative regulation of smoothened signaling pathwaIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006914autophagyTASbiological_process
GO:0045880positive regulation of smoothened signaling pathwaIDAbiological_process
GO:0090398cellular senescenceTASbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function


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