| UniProt/SwissProt ID: | TYK2_HUMAN |
| Description: | tyrosine kinase 2 [Source:HGNC Symbol;Acc:12440] |
| Location: | chr19 p13.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1054 | PEGHEyYRVRE | JAK1 | HPRD; phosphoELM; RegPhos |
| Y851 | SQCLTyEPTQR | Pkinase_Tyr | PhosphoSitePlus |
| Y433 | ADSSHyLCHEV | PhosphoSitePlus | |
| Y1054 | PEGHEyYRVRE | phosphoELM | |
| Y1054 | PEGHEyYRVRE | autocatalysis | RegPhos |
| S499 | PDGMQsLRLRK | PhosphoSitePlus; HPRD; SysPTM | |
| Y1055 | EGHEYyRVRED | Pkinase_Tyr | PhosphoSitePlus |
| Y423 | SLVDGyFRLTA | PhosphoSitePlus | |
| Y1055 | EGHEYyRVRED | JAK1 | HPRD; phosphoELM; RegPhos |
| Y291 | AEGEPcYIRDS | HPRD | |
| S884 | TVNPDsPASDP | PhosphoSitePlus; HPRD; SysPTM | |
| Y1055 | EGHEYyRVRED | Tyk2 | phosphoELM; RegPhos |
| Y1054 | PEGHEyYRVRE | Pkinase_Tyr | PhosphoSitePlus |
| Y1055 | EGHEYyRVRED | phosphoELM | |
| S577 | RTLNLsQLSFH | PhosphoSitePlus | |
| Y292 | EGEPCyIRDSG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Y827 | EKEHFyQRQHR | Pkinase_Tyr | PhosphoSitePlus |
| S339 | NKEEGsSGSSG | PhosphoSitePlus | |
| Y1145 | CPCEVyHLMKN | Pkinase_Tyr | PhosphoSitePlus |
| Y1054 | PEGHEyYRVRE | Tyk2 | phosphoELM; RegPhos |
| S340 | KEEGSsGSSGR | PhosphoSitePlus | |
| Y604 | TRTNVyEGRLR | RegPhos | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1054 | AVPEGHEyYRVREDG | PTPRC | HPRD |
| Y1055 | VPEGHEYyRVREDGD | PTPRC | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264818 | H732R | HPI | Colorectal Cancer | 17344846 | ENSP00000264818 | L1109F | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000264818 | S394N | COSMIC | Lung Cancer | 20668451 | ENSP00000264818 | V298E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264818 | S1182L | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000431885 | C1187F | COSMIC | Lung Cancer | 20668451 | ENSP00000431885 | L1109F | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000264818 | C1187F | COSMIC | Lung Cancer | 20668451 | ENSP00000264818 | H732R | Greenman2007, COSMIC | Intestines Cancer | 17344846, 18428421 | ENSP00000264818 | A1069G | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000431885 | H732R | COSMIC | Intestines Cancer | ENSP00000264818 | R231Q | COSMIC | Lung Cancer | 20668451 | ENSP00000431885 | V298E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000431885 | M795V | COSMIC | Ovarian Cancer | 20668451 | ENSP00000431885 | R231Q | COSMIC | Lung Cancer | 20668451 | ENSP00000431885 | S1182L | COSMIC | Lung Cancer | 18948947 | ENSP00000431885 | A1069G | COSMIC | Lung Cancer | 18948947 | ENSP00000264818 | M795V | COSMIC | Ovarian Cancer | 20668451 | ENSP00000431885 | S394N | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000264818 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 19007971 | |
| Hyperphosphorylation site |
| TYK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | TYK2_HUMAN | kinase -> substrate | RegPhos |
| TYK2_HUMAN | ZYX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | GBLP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | NPM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | HCLS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | PP1R8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | NAR4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| JAK1_HUMAN | TYK2_HUMAN | kinase -> substrate | RegPhos |
| TYK2_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | TYK2_HUMAN | kinase -> substrate | NetPath |
| TYK2_HUMAN | IRF3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | INAR1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| TYK2_HUMAN | E2AK2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | GCFC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | 1433E_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | BCL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | TE2IP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | I10R1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | HNRPK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | SMRC2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | STAT1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PTPRC_HUMAN | TYK2_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05168 | Herpes simplex infection |
| hsa05169 | Epstein-Barr virus infection |
| hsa05164 | Influenza A |
| hsa04380 | Osteoclast differentiation |
| hsa05160 | Hepatitis C |
| hsa05162 | Measles |
| hsa05145 | Toxoplasmosis |
| hsa04630 | Jak-STAT signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0060337 | type I interferon-mediated signaling pathway | TAS | biological_process |
| GO:0007243 | intracellular protein kinase cascade | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004715 | non-membrane spanning protein tyrosine kinase acti | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0005131 | growth hormone receptor binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0060338 | regulation of type I interferon-mediated signaling | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005856 | cytoskeleton | IEA | cellular_component |