| UniProt/SwissProt ID: | PCGF6_HUMAN |
| Description: | polycomb group ring finger 6 [Source:HGNC Symbol;Acc:21156] |
| Location: | chr10 q24.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S115 | GGRQDsEDEEE | HPRD | |
| S115 | GGRQDsEDEEE | Daxx; BUD22 | PhosphoSitePlus |
| S30 | PPPPVsPPALT | PhosphoSitePlus; RegPhos | |
| T284 | VSGEAtIGHVE | PhosphoSitePlus; HPRD | |
| S205 | KFVRVsGEATI | HPRD | |
| S280 | KFVRVsGEATI | PhosphoSitePlus; HPRD | |
| S105 | DMSHFsLRLEG | Daxx; BUD22 | PhosphoSitePlus |
| S30 | PPPPVsPPALT | CDK7 | HPRD; RegPhos |
| T209 | VSGEAtIGHVE | HPRD | |
| T8 | GVAVVtAGSVG | PhosphoSitePlus | |
| Dephosphorylation site |
| PCGF6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000338845 | R218G | COSMIC | Renal Cancer | ENSP00000358862 | R293G | COSMIC | Renal Cancer |
| Differential expressed protein |
| PCGF6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PCGF6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | PCGF6_HUMAN | kinase -> substrate | RegPhos |
| CDK7_HUMAN | PCGF6_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| PCGF6_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0031519 | PcG protein complex | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0035102 | PRC1 complex | IDA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |