Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CNOT6_HUMAN
Description:CCR4-NOT transcription complex, subunit 6 [Source:HGNC Symbol;Acc:14099]
Location:chr5 q35.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T447YNESLtNFSCHExo_endo_phosPhosphoSitePlus
S445LRYNEsLTNFSExo_endo_phosPhosphoSitePlus
S212YGYCPsWALNWExo_endo_phosPhosphoSitePlus
S42SGKVRsLSASLPhosphoSitePlus
T54SLTHLtALHLSLRR_4PhosphoSitePlus
Y201VLCDKyATRQLExo_endo_phosPhosphoSitePlus
S49SASLWsLTHLTPhosphoSitePlus

Dephosphorylation site
CNOT6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377024P406LCOSMICSkin Cancer21984974

Differential expressed protein
CNOT6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CNOT6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK6_HUMANCNOT6_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANCNOT6_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANCNOT6_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANCNOT6_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
CNOT6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000289nuclear-transcribed mRNA poly(A) tail shorteningTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0004535poly(A)-specific ribonuclease activityTASmolecular_function
GO:0016071mRNA metabolic processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0003723RNA bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:2000327positive regulation of ligand-dependent nuclear reIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0000288nuclear-transcribed mRNA catabolic process, deadenTASbiological_process


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