Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ICK_HUMAN
Description:intestinal cell (MAK-like) kinase [Source:HGNC Symbol;Acc:21219]
Location:chr6 p12.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y159PPYTDyVSTRWHPRD; phosphoELM; RegPhos
T157SKPPYtDYVSTPkinasePhosphoSitePlus
S53LREVKsLKKLNPkinasePhosphoSitePlus
Y156RSKPPyTDYVSHPRD; phosphoELM
S23VLLGRsIESGEPkinasePhosphoSitePlus
T463SEPVGtGNSAPPhosphoSitePlus
T14QLGDGtYGSVLPkinasePhosphoSitePlus
S254LIPNAsSEAVQPkinasePhosphoSitePlus
S254LIPNAsSEAVQHPRD
T157SKPPYtDYVSTCDK7phosphoELM; RegPhos
S17DGTYGsVLLGRPkinasePhosphoSitePlus
T157SKPPYtDYVSTHPRD; RegPhos
Y583DPSPGySSLKAPhosphoSitePlus
T14QLGDGtYGSVLRegPhos
S585SPGYSsLKAMRPhosphoSitePlus
Y156RSKPPyTDYVSPkinasePhosphoSitePlus
T248PNNLKtLIPNAPkinasePhosphoSitePlus
Y159PPYTDyVSTRWICKphosphoELM; RegPhos
Y177LRSTNySSPIDPkinasePhosphoSitePlus
Y15LGDGTyGSVLLRegPhos
Y159PPYTDyVSTRWPkinasePhosphoSitePlus

Dephosphorylation site
ICK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263043F115YGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000349458F115YGreenman2007, HPIRenal Cancer17344846, 18428421

Differential expressed protein
ICK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ICK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK7_HUMANICK_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANICK_HUMANkinase -> substrateRegPhos
ICK_HUMANICK_HUMANkinase -> substrateRegPhos
ICK_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ICK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004693cyclin-dependent protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0005829cytosolIEAcellular_component


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