| UniProt/SwissProt ID: | SET_HUMAN |
| Description: | SET nuclear oncogene [Source:HGNC Symbol;Acc:10760] |
| Location: | chr9 q34.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S15 | KKELNsNHDGA | HPRD | |
| S9 | PAAKVsKKELN | HPRD | |
| S7 | LPPQ | phosphoELM; SysPTM | |
| S50 | LNEQAsEEILK | HPRD | |
| T23 | DGADEtSEKEQ | HPRD | |
| Y146 | FDENPyFENKV | NAP | PhosphoSitePlus |
| S191 | TQNKAsRKRQH | NAP | PhosphoSitePlus |
| Y119 | EEALHyLTRVE | NAP | PhosphoSitePlus |
| S161 | FHLNEsGDPSS | NAP | PhosphoSitePlus |
| S63 | LNEQAsEEILK | NAP | PhosphoSitePlus |
| S24 | GADETsEKEQQ | HPRD | |
| S7 | APKRQsPLPPQ | PhosphoSitePlus; SysPTM | |
| Y140 | YRIDFyFDENP | NAP | PhosphoSitePlus |
| S148 | FHLNEsGDPSS | HPRD | |
| Dephosphorylation site |
| SET_HUMAN do not have dephosphorylation site. |
| Mutation site |
| SET_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000361777 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000361777 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.37 | 19142970 | ENSP00000361777 | Neoplasms by Histologic Type | Cancer vs. Cancer | cell line | Up | 15750928 | ENSP00000361777 | Neoplasms by Histologic Type | Cancer vs. Cancer | cell line | Up | 15750928 | ENSP00000361777 | Gastric Cancer | Treatment (none vs. Vincristine-resistant) | cell line | Down | 0.17 | 18253933 | ENSP00000361777 | Oral Cancer | Normal vs. Cancer | tissue | Up | 5.9 | 19691830 | ENSP00000361777 | Ovarian Cancer | Treatment (Paclitaxel-sensitive vs. Paclitaxel-resistant) | cell line | Down | 0.44 | 20858016 | ENSP00000361777 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Up | 1.3 | 20625496 |
| Hyperphosphorylation site |
| SET_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK6_HUMAN | SET_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK7_HUMAN | SET_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SET_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0004864 | protein phosphatase inhibitor activity | TAS | molecular_function |
| GO:0043524 | negative regulation of neuron apoptotic process | IGI | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0043234 | protein complex | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0042393 | histone binding | TAS | molecular_function |
| GO:0005783 | endoplasmic reticulum | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0008601 | protein phosphatase type 2A regulator activity | TAS | molecular_function |
| GO:0006913 | nucleocytoplasmic transport | NAS | biological_process |
| GO:0035067 | negative regulation of histone acetylation | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006337 | nucleosome disassembly | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006334 | nucleosome assembly | IEA | biological_process |