Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SET_HUMAN
Description:SET nuclear oncogene [Source:HGNC Symbol;Acc:10760]
Location:chr9 q34.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S15KKELNsNHDGAHPRD
S9PAAKVsKKELNHPRD
S7LPPQphosphoELM; SysPTM
S50LNEQAsEEILKHPRD
T23DGADEtSEKEQHPRD
Y146FDENPyFENKVNAPPhosphoSitePlus
S191TQNKAsRKRQHNAPPhosphoSitePlus
Y119EEALHyLTRVENAPPhosphoSitePlus
S161FHLNEsGDPSSNAPPhosphoSitePlus
S63LNEQAsEEILKNAPPhosphoSitePlus
S24GADETsEKEQQHPRD
S7APKRQsPLPPQPhosphoSitePlus; SysPTM
Y140YRIDFyFDENPNAPPhosphoSitePlus
S148FHLNEsGDPSSHPRD

Dephosphorylation site
SET_HUMAN do not have dephosphorylation site.

Mutation site
SET_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000361777Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000361777Esophageal CancerNormal vs. CancertissueDown0.3719142970
ENSP00000361777Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000361777Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000361777Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineDown0.1718253933
ENSP00000361777Oral CancerNormal vs. CancertissueUp5.919691830
ENSP00000361777Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.4420858016
ENSP00000361777Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.320625496

Hyperphosphorylation site
SET_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK6_HUMANSET_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANSET_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SET_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016071mRNA metabolic processTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005829cytosolIEAcellular_component
GO:0004864protein phosphatase inhibitor activityTASmolecular_function
GO:0043524negative regulation of neuron apoptotic processIGIbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0043234protein complexIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0042393histone bindingTASmolecular_function
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0008601protein phosphatase type 2A regulator activityTASmolecular_function
GO:0006913nucleocytoplasmic transportNASbiological_process
GO:0035067negative regulation of histone acetylationTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006260DNA replicationTASbiological_process
GO:0006337nucleosome disassemblyTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0006334nucleosome assemblyIEAbiological_process


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