UniProt/SwissProt ID: | PER1_HUMAN |
Description: | period circadian clock 1 [Source:HGNC Symbol;Acc:8845] |
Location: | chr17 p13.1 |
Node attribute: | PPI(source); substrate; PPI(target) |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S159 | RGKGRsGTLAT | PhosphoSitePlus | |
S72 | QRSSHsSSSGN | PhosphoSitePlus | |
S1103 | FGSIDsSEAEA | PhosphoSitePlus; HPRD | |
S979 | FNSRCsSPLQL | PhosphoSitePlus; HPRD; phosphoELM | |
S1262 | GAKASsSQDLA | PhosphoSitePlus; HPRD; phosphoELM | |
S1186 | LGAVHsWVRKG | PhosphoSitePlus; HPRD; SysPTM | |
T702 | PVVGGtLSPLA | PhosphoSitePlus | |
S1276 | EEEGRsSSSPA | PhosphoSitePlus | |
T164 | SGTLAtLQYAL | PhosphoSitePlus; HPRD | |
S980 | NSRCSsPLQLN | PhosphoSitePlus; HPRD; phosphoELM | |
S837 | RHHCRsKAKRS | PhosphoSitePlus | |
S1100 | SKYFGsIDSSE | PhosphoSitePlus; HPRD | |
T677 | PVSVGtKKDPP | PhosphoSitePlus | |
T692 | SGEGAtPRKEP | PhosphoSitePlus | |
S1279 | GRSSSsPALPT | PhosphoSitePlus; HPRD | |
S757 | PGPAPsPAPSP | PhosphoSitePlus | |
Y167 | LATLQyALACV | PhosphoSitePlus | |
S592 | ALPCQsPDPEL | PhosphoSitePlus | |
S1104 | GSIDSsEAEAG | PhosphoSitePlus; HPRD | |
Y107 | SSSIAySLLSA | PhosphoSitePlus | |
S704 | VGGTLsPLALA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
S1263 | AKASSsQDLAM | PhosphoSitePlus; HPRD; phosphoELM | |
T161 | KGRSGtLATLQ | PhosphoSitePlus; HPRD | |
S815 | SSTAPsALGER | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
Dephosphorylation site |
PER1_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000314420 | Q846* | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000314420 | P403A | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000314420 | S1060L | HPI | Colorectal Cancer | 16959974 |
ENSP00000314420 | E696Q | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 |
ENSP00000314420 | D218N | COSMIC | Melanoma | |
ENSP00000314420 | P355S | COSMIC | Melanoma | 21499247 |
ENSP00000314420 | N985S | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 |
ENSP00000314420 | R1162W | COSMIC | Lung Cancer | 20668451 |
ENSP00000314420 | S1060L | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 |
ENSP00000314420 | L397M | COSMIC | Head and Neck Cancer | 21798893 |
Differential expressed protein |
PER1_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
PER1_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
KC1D_HUMAN | PER1_HUMAN | kinase -> substrate | KEGG |
STK4_HUMAN | PER1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
DDR1_HUMAN | PER1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
CDK7_HUMAN | PER1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
AURKB_HUMAN | PER1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
PER1_HUMAN | PER1_HUMAN | other | KEGG |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04710 | Circadian rhythm - mammal |
hsa05168 | Herpes simplex infection |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0007165 | signal transduction | IEA | biological_process |
GO:0005737 | cytoplasm | IEA | cellular_component |
GO:0007623 | circadian rhythm | IEA | biological_process |
GO:0070888 | E-box binding | IDA | molecular_function |
GO:0032922 | circadian regulation of gene expression | IDA | biological_process |
GO:0000988 | protein binding transcription factor activity | IEA | molecular_function |
GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
GO:0045892 | negative regulation of transcription, DNA-dependen | ISS | biological_process |
GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
GO:0009416 | response to light stimulus | IEA | biological_process |
GO:0000978 | RNA polymerase II core promoter proximal region se | IDA | molecular_function |
GO:0005634 | nucleus | IEA | cellular_component |
GO:0009649 | entrainment of circadian clock | TAS | biological_process |
GO:0004871 | signal transducer activity | IEA | molecular_function |
GO:0005515 | protein binding | IEA | molecular_function |