| UniProt/SwissProt ID: | DCLK2_HUMAN |
| Description: | doublecortin-like kinase 2 [Source:HGNC Symbol;Acc:19002] |
| Location: | chr4 q31.23 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y505 | ANALRyLHGLS | Pkinase_CAMK | PhosphoSitePlus |
| S182 | LAAASsVKSEV | PhosphoSitePlus; HPRD | |
| Y83 | RNGDRyFKGLV | PhosphoSitePlus | |
| S93 | VFAISsDRFRS | DCX | PhosphoSitePlus |
| S185 | ASSVKsEVKES | PhosphoSitePlus | |
| T173 | NIKGGtSRALA | PhosphoSitePlus | |
| S347 | PTSPGsFRGLK | PhosphoSitePlus | |
| T61 | FYRTRtLQALS | PhosphoSitePlus | |
| T685 | QNSTTtGVSVI | PhosphoSitePlus | |
| S340 | TKSSSsSPTSP | PhosphoSitePlus | |
| S308 | YSGSKsPGPSR | PhosphoSitePlus | |
| T331 | SSQLStPKSTK | PhosphoSitePlus | |
| S344 | SSSPTsPGSFR | PhosphoSitePlus | |
| S312 | KSPGPsRRSKS | PhosphoSitePlus | |
| S6 | MASTRsIELEH | PhosphoSitePlus | |
| Dephosphorylation site |
| DCLK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000296550 | C524W | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000303887 | D496N | COSMIC | Gastric Cancer | 21097718 | ENSP00000296550 | H435R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000296550 | E594K | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| DCLK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DCLK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DCLK2_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DCLK2_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| DCLK2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |