| UniProt/SwissProt ID: | VRK1_HUMAN |
| Description: | vaccinia related kinase 1 [Source:HGNC Symbol;Acc:12718] |
| Location: | chr14 q32.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S158 | TVLQLsLRILD | HPRD | |
| T378 | TEWSNtQTEEA | PhosphoSitePlus; HPRD | |
| S342 | GKLDLsVVENG | PLK3 | HPRD |
| T305 | AKYMEtVKLLD | HPRD; phosphoELM | |
| T153 | RFSRKtVLQLS | HPRD | |
| S158 | TVLQLsLRILD | Pkinase | PhosphoSitePlus |
| T355 | KAKTItKKRKK | PhosphoSitePlus; HPRD; phosphoELM | |
| S376 | EDTEWsNTQTE | PhosphoSitePlus; HPRD | |
| T380 | WSNTQtEEAIQ | PhosphoSitePlus | |
| T390 | QTRSRtRKRV | HPRD; phosphoELM | |
| T153 | RFSRKtVLQLS | Pkinase | PhosphoSitePlus |
| S342 | GKLDLsVVENG | PhosphoSitePlus | |
| Dephosphorylation site |
| VRK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| VRK1_HUMAN do not have mutation site. |
| Differential expressed protein |
| VRK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| VRK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| VRK1_HUMAN | XRCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| VRK1_HUMAN | P53_HUMAN | kinase -> substrate | HPRD; RegPhos |
| VRK1_HUMAN | MRF_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| VRK1_HUMAN | HSFX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| VRK1_HUMAN | ATF2_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| VRK1_HUMAN | JUN_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| VRK1_HUMAN | TOX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PLK3_HUMAN | VRK1_HUMAN | kinase -> substrate | HPRD |
| VRK1_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| VRK1_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| VRK1_HUMAN | AIRE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| VRK1_HUMAN | NDF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| VRK1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0046777 | protein autophosphorylation | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0005795 | Golgi stack | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005819 | spindle | IEA | cellular_component |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0090166 | Golgi disassembly | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |