| UniProt/SwissProt ID: | FR1OP_HUMAN |
| Description: | FGFR1 oncogene partner [Source:HGNC Symbol;Acc:17012] |
| Location: | chr6 q27 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S209 | TSVSLsEPKSK | PhosphoSitePlus; HPRD | |
| S61 | PLVNEsLKKFL | FOP_dimer | PhosphoSitePlus |
| S202 | DEANQsDTSVS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S189 | TSVSLsEPKSK | HPRD | |
| S279 | RKQAGsLASLS | PhosphoSitePlus | |
| Y394 | SDVADyLEDVA | PhosphoSitePlus | |
| S262 | AGSLAsLSDAP | HPRD | |
| T170 | TSAQTtPSKIP | PhosphoSitePlus | |
| Y337 | GEDDDyVDDFN | PhosphoSitePlus; SysPTM | |
| S234 | DMEGDsFFDDP | HPRD | |
| T169 | KTSAQtTPSKI | PhosphoSitePlus | |
| T165 | SPEGKtSAQTT | PhosphoSitePlus | |
| S160 | HSPPKsPEGKT | PhosphoSitePlus; HPRD; phosphoELM | |
| S254 | DMEGDsFFDDP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T204 | ANQSDtSVSLS | PhosphoSitePlus; HPRD | |
| S389 | TVSQLsDVADY | PhosphoSitePlus | |
| T4 | __MAAtAAAVV | PhosphoSitePlus | |
| S282 | AGSLAsLSDAP | HPRD | |
| S301 | LAGAPsLKDSE | PhosphoSitePlus | |
| T55 | KVENKtPLVNE | FOP_dimer | PhosphoSitePlus |
| S156 | LSDVHsPPKSP | PhosphoSitePlus; HPRD; phosphoELM | |
| S172 | AQTTPsKIPRY | PhosphoSitePlus | |
| S182 | DEANQsDTSVS | HPRD | |
| S152 | GALDLsDVHSP | PhosphoSitePlus; HPRD; phosphoELM | |
| S291 | APPLKsGLSSL | PhosphoSitePlus | |
| T184 | ANQSDtSVSLS | HPRD | |
| Dephosphorylation site |
| FR1OP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000230248 | G272E | COSMIC | Ovarian Cancer | 20668451 |
| Differential expressed protein |
| FR1OP_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FR1OP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KS6B1_HUMAN | FR1OP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1B_HUMAN | FR1OP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | FR1OP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| FR1OP_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006469 | negative regulation of protein kinase activity | IDA | biological_process |
| GO:0034453 | microtubule anchoring | IEA | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0030335 | positive regulation of cell migration | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008284 | positive regulation of cell proliferation | IDA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | TAS | molecular_function |
| GO:0030292 | protein tyrosine kinase inhibitor activity | IDA | molecular_function |
| GO:0005815 | microtubule organizing center | IEA | cellular_component |
| GO:0042803 | protein homodimerization activity | IDA | molecular_function |
| GO:0005813 | centrosome | IDA | cellular_component |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0030307 | positive regulation of cell growth | IDA | biological_process |
| GO:0061099 | negative regulation of protein tyrosine kinase act | IDA | biological_process |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |