Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FR1OP_HUMAN
Description:FGFR1 oncogene partner [Source:HGNC Symbol;Acc:17012]
Location:chr6 q27
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S209TSVSLsEPKSKPhosphoSitePlus; HPRD
S61PLVNEsLKKFLFOP_dimerPhosphoSitePlus
S202DEANQsDTSVSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S189TSVSLsEPKSKHPRD
S279RKQAGsLASLSPhosphoSitePlus
Y394SDVADyLEDVAPhosphoSitePlus
S262AGSLAsLSDAPHPRD
T170TSAQTtPSKIPPhosphoSitePlus
Y337GEDDDyVDDFNPhosphoSitePlus; SysPTM
S234DMEGDsFFDDPHPRD
T169KTSAQtTPSKIPhosphoSitePlus
T165SPEGKtSAQTTPhosphoSitePlus
S160HSPPKsPEGKTPhosphoSitePlus; HPRD; phosphoELM
S254DMEGDsFFDDPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T204ANQSDtSVSLSPhosphoSitePlus; HPRD
S389TVSQLsDVADYPhosphoSitePlus
T4__MAAtAAAVVPhosphoSitePlus
S282AGSLAsLSDAPHPRD
S301LAGAPsLKDSEPhosphoSitePlus
T55KVENKtPLVNEFOP_dimerPhosphoSitePlus
S156LSDVHsPPKSPPhosphoSitePlus; HPRD; phosphoELM
S172AQTTPsKIPRYPhosphoSitePlus
S182DEANQsDTSVSHPRD
S152GALDLsDVHSPPhosphoSitePlus; HPRD; phosphoELM
S291APPLKsGLSSLPhosphoSitePlus
T184ANQSDtSVSLSHPRD

Dephosphorylation site
FR1OP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000230248G272ECOSMICOvarian Cancer20668451

Differential expressed protein
FR1OP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FR1OP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6B1_HUMANFR1OP_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANFR1OP_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANFR1OP_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
FR1OP_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006469negative regulation of protein kinase activityIDAbiological_process
GO:0034453microtubule anchoringIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0030292protein tyrosine kinase inhibitor activityIDAmolecular_function
GO:0005815microtubule organizing centerIEAcellular_component
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005813centrosomeIDAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0030307positive regulation of cell growthIDAbiological_process
GO:0061099negative regulation of protein tyrosine kinase actIDAbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0005829cytosolTAScellular_component


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