| UniProt/SwissProt ID: | SYNJ2_HUMAN |
| Description: | synaptojanin 2 [Source:HGNC Symbol;Acc:11504] |
| Location: | chr6 q25.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1433 | TWLSKsSDPLD | PhosphoSitePlus | |
| S994 | SPTANsCLLEE | PhosphoSitePlus | |
| T1220 | AAKPEtPQAPP | PhosphoSitePlus | |
| S1191 | ARGGAsEEALS | PhosphoSitePlus; HPRD | |
| S1318 | PGAGAsVPPPL | PhosphoSitePlus | |
| T991 | APVSPtANSCL | PhosphoSitePlus | |
| S825 | LNLLDsDLDVD | Exo_endo_phos | PhosphoSitePlus; SysPTM |
| S1434 | WLSKSsDPLDS | PhosphoSitePlus | |
| Y1136 | GTHGQySILQT | PhosphoSitePlus | |
| S4 | __MALsKGLRL | PhosphoSitePlus | |
| Y490 | LVGDVyGEEVA | PhosphoSitePlus | |
| S1124 | VKKSAsDASIS | PhosphoSitePlus | |
| Y130 | SSGVFyFSWPN | HPRD; phosphoELM | |
| S1196 | SEEALsAVAPR | PhosphoSitePlus | |
| S1122 | LMVKKsASDAS | PhosphoSitePlus | |
| S921 | MQTLGsYGTIV | PhosphoSitePlus | |
| Y130 | SSGVFyFSWPN | Syja_N | PhosphoSitePlus |
| T1441 | PLDSGtRSPKR | PhosphoSitePlus | |
| Y61 | KLTDAyGCLGE | Syja_N | PhosphoSitePlus |
| S825 | LNLLDsDLDVD | HPRD; SysPTM | |
| T918 | TELMQtLGSYG | PhosphoSitePlus | |
| Y1411 | PLLGDyQDPFW | PhosphoSitePlus | |
| S1439 | SDPLDsGTRSP | PhosphoSitePlus | |
| Dephosphorylation site |
| SYNJ2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000347792 | M534I | COSMIC | Skin Cancer | 21984974 | ENSP00000347792 | R617C | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| SYNJ2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SYNJ2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KS6B1_HUMAN | SYNJ2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | SYNJ2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SYNJ2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0006644 | phospholipid metabolic process | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0046854 | phosphatidylinositol phosphorylation | IEA | biological_process |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0042578 | phosphoric ester hydrolase activity | IEA | molecular_function |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatas | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |