| UniProt/SwissProt ID: | NXF3_HUMAN |
| Description: | nuclear RNA export factor 3 [Source:HGNC Symbol;Acc:8073] |
| Location: | chrX q22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y407 | ILKDPyLRGEL | NTF2 | PhosphoSitePlus |
| Y124 | PFGIKyNEKWL | Tap-RNA_bind | PhosphoSitePlus |
| Dephosphorylation site |
| NXF3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000378504 | *532R | COSMIC | Breast Cancer | 20668451 | ENSP00000378504 | P140T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000378504 | T9K | COSMIC | Lung Cancer | ENSP00000378504 | Q134H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000378504 | S517T | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| NXF3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NXF3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| EF2K_HUMAN | NXF3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B1_HUMAN | NXF3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NXF3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0016973 | poly(A)+ mRNA export from nucleus | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0003729 | mRNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006406 | mRNA export from nucleus | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042272 | nuclear RNA export factor complex | IDA | cellular_component |
| GO:0006810 | transport | IEA | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0000166 | nucleotide binding | IEA | molecular_function |