| UniProt/SwissProt ID: | SMCE1_HUMAN |
| Description: | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [Source:HGNC Symbol;Acc:11109] |
| Location: | chr17 q21.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y73 | KPLMPyMRYSR | HMG_box | PhosphoSitePlus |
| S314 | EQAERsQSSIV | HPRD | |
| T58 | ASSGItIPKPP | PhosphoSitePlus; HPRD | |
| S187 | YDDGFsMKHTA | HPRD | |
| S265 | LESTDsFNNEL | PhosphoSitePlus | |
| Y28 | PGFVGyNPYSH | PhosphoSitePlus | |
| Y142 | PAYLAyINAKS | PhosphoSitePlus | |
| S55 | RVTASsGITIP | HPRD | |
| S6 | MSKRPsYAPPP | PhosphoSitePlus | |
| T350 | THLEEtTESQQ | PhosphoSitePlus | |
| T17 | TPAPAtQMPST | PhosphoSitePlus | |
| S157 | ALEEEsRQRQS | PhosphoSitePlus; HPRD | |
| S353 | EETTEsQQNGE | PhosphoSitePlus | |
| Y31 | VGYNPySHLAY | PhosphoSitePlus | |
| S32 | GYNPYsHLAYN | PhosphoSitePlus | |
| S21 | ATQMPsTPGFV | PhosphoSitePlus | |
| T263 | KFLEStDSFNN | PhosphoSitePlus | |
| T363 | EEGTStPEDKE | PhosphoSitePlus; HPRD | |
| T22 | TQMPStPGFVG | PhosphoSitePlus | |
| Y170 | EKGEPyMSIQP | PhosphoSitePlus | |
| S362 | GEEGTsTPEDK | PhosphoSitePlus | |
| Y7 | SKRPSyAPPPT | PhosphoSitePlus | |
| T12 | YAPPPtPAPAT | PhosphoSitePlus | |
| Y182 | EDPDDyDDGFS | HPRD | |
| Y139 | HNSPAyLAYIN | PhosphoSitePlus | |
| Dephosphorylation site |
| SMCE1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000323967 | E261* | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| SMCE1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SMCE1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KS6B1_HUMAN | SMCE1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SMCE1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003682 | chromatin binding | TAS | molecular_function |
| GO:0006337 | nucleosome disassembly | IDA | biological_process |
| GO:0000228 | nuclear chromosome | TAS | cellular_component |
| GO:0008080 | N-acetyltransferase activity | IDA | molecular_function |
| GO:0006357 | regulation of transcription from RNA polymerase II | NAS | biological_process |
| GO:0003713 | transcription coactivator activity | NAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016514 | SWI/SNF complex | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0006338 | chromatin remodeling | IDA | biological_process |
| GO:0071565 | nBAF complex | IEA | cellular_component |
| GO:0047485 | protein N-terminus binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0017053 | transcriptional repressor complex | IPI | cellular_component |
| GO:0071564 | npBAF complex | IEA | cellular_component |
| GO:0007399 | nervous system development | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016922 | ligand-dependent nuclear receptor binding | IPI | molecular_function |