| UniProt/SwissProt ID: | CLK2_HUMAN |
| Description: | CDC-like kinase 2 [Source:HGNC Symbol;Acc:2069] |
| Location: | chr1 q22 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S64 | YDDRSsDRRVY | PhosphoSitePlus | |
| S50 | RRREDsYHVRS | PhosphoSitePlus | |
| S14 | SSERGsRGSYR | PhosphoSitePlus | |
| T127 | RRRSRtFSRSS | PhosphoSitePlus | |
| S142 | SRRAKsVEDDA | PhosphoSitePlus; phosphoELM | |
| Y51 | RREDSyHVRSR | PhosphoSitePlus | |
| S63 | SYDDRsSDRRV | PhosphoSitePlus | |
| Y82 | YRRNDySRDRG | PhosphoSitePlus | |
| S58 | VRSRSsYDDRS | PhosphoSitePlus | |
| Y69 | SDRRVyDRRYC | PhosphoSitePlus | |
| Y7 | PHPRRyHSSER | PhosphoSitePlus | |
| Y59 | RSRSSyDDRSS | PhosphoSitePlus | |
| S98 | TDYRHsYEYQR | PhosphoSitePlus | |
| Y101 | RHSYEyQRENS | PhosphoSitePlus | |
| Y430 | TSAGRyVRENC | Pkinase | PhosphoSitePlus |
| S17 | RGSRGsYREHY | PhosphoSitePlus | |
| S402 | LGPIPsRMIRK | Pkinase | PhosphoSitePlus |
| S34 | RRRSRsWSSSS | PhosphoSitePlus | |
| S106 | YQRENsSYRSQ | PhosphoSitePlus | |
| S9 | PRRYHsSERGS | PhosphoSitePlus | |
| S493 | NKLWDsSRDIS | PhosphoSitePlus | |
| Y95 | YYDTDyRHSYE | PhosphoSitePlus | |
| S83 | RRNDYsRDRGD | PhosphoSitePlus | |
| Y153 | EGHLIyHVGDW | PhosphoSitePlus | |
| S10 | RRYHSsERGSR | PhosphoSitePlus | |
| S167 | RYEIVsTLGEG | Pkinase | PhosphoSitePlus |
| Y91 | RGDAYyDTDYR | PhosphoSitePlus | |
| Dephosphorylation site |
| CLK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CLK2_HUMAN do not have mutation site. |
| Differential expressed protein |
| CLK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CLK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK2_HUMAN | ZIC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | FEV_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | EI2BE_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | KHDR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | TOX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | RFA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | RPAC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | TBX20_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | GTD2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | FHL2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | M18BP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | ZN784_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | PPP5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | BCL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | PRD10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | ZEB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | TCP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | RMP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | SMAD4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | NCBP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | BAD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | Z280D_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | SMPX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | PP1R8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | CSDC2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | ARI3A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | XPA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | DX39A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | MATR3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | ZNF32_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | SRSF2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | ZN606_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | U2AF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | NOL7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | SPF30_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | ZMYM3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | RBM12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | PTN1_HUMAN | kinase -> substrate | RegPhos |
| CLK2_HUMAN | CP250_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | IASPP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | 1433F_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | MDFI_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | EGFR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | XPO1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | PRS6A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | MDM2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | ZYX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | HSFX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | COE4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | GPBL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | ZN823_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| CLK2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0045721 | negative regulation of gluconeogenesis | ISS | biological_process |
| GO:0046777 | protein autophosphorylation | ISS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0043484 | regulation of RNA splicing | IDA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0010212 | response to ionizing radiation | IMP | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0045721 | negative regulation of gluconeogenesis | IEA | biological_process |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0042221 | response to chemical stimulus | IEA | biological_process |
| GO:0032526 | response to retinoic acid | IEA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0046777 | protein autophosphorylation | IEA | biological_process |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |