Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:U2AF1_HUMAN
Description:U2 small nuclear RNA auxiliary factor 1 [Source:HGNC Symbol;Acc:12453]
Location:chr21 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S7AEYLAsIFGTEPhosphoSitePlus
S231RDRRRsRDRERPhosphoSitePlus
S122RKKHRsRSRSRHPRD
S70LRCAVsDVEMQPhosphoSitePlus; HPRD
S204SRERRsRSRDRPhosphoSitePlus
T11ASIFGtEKDKVPhosphoSitePlus
Y93EMEEKyGEVEERRM_1PhosphoSitePlus
S124KHRSRsRSRERHPRD
S197KHRSRsRSRERHPRD
S206ERRSRsRDRGRPhosphoSitePlus
S195RKKHRsRSRSRHPRD
S61QNSSQsADGLRPhosphoSitePlus; HPRD
T87FEEVFtEMEEKPhosphoSitePlus; HPRD
S19DKVNCsFYFKIHPRD
S59NPQNSsQSADGPhosphoSitePlus; HPRD; phosphoELM
S237RDRERsGRF__PhosphoSitePlus
Y4__MAEyLASIFPhosphoSitePlus
S19DKVNCsFYFKIzf-CCCHPhosphoSitePlus

Dephosphorylation site
U2AF1_HUMAN do not have dephosphorylation site.

Mutation site
U2AF1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000291552Gastric CancerMetastasiscell lineUp1.617022644
ENSP00000291552Gastric CancerMetastasiscell lineUp1.617022644

Hyperphosphorylation site
U2AF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLK2_HUMANU2AF1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
U2AF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006397mRNA processingTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0006369termination of RNA polymerase II transcriptionTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0006406mRNA export from nucleusTASbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0031124mRNA 3'-end processingTASbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0050733RS domain bindingIEAmolecular_function
GO:0005681spliceosomal complexIDAcellular_component
GO:0016607nuclear speckIEAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0015030Cajal bodyTAScellular_component
GO:0016607nuclear speckISScellular_component
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0008380RNA splicingTASbiological_process


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