| UniProt/SwissProt ID: | PRD10_HUMAN |
| Description: | PR domain containing 10 [Source:HGNC Symbol;Acc:13995] |
| Location: | chr11 q24.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S424 | ENGEKsDDGTQ | PhosphoSitePlus; HPRD | |
| S341 | KIHDIsEEERK | DUF629 | PhosphoSitePlus |
| S708 | KADRIsRSKTF | PhosphoSitePlus | |
| S338 | ENGEKsDDGTQ | HPRD; phosphoELM | |
| T417 | IRLEItSENGE | HPRD | |
| S418 | RLEITsENGEK | PhosphoSitePlus | |
| S964 | YVLSEsQSELE | HPRD | |
| S1002 | YVLSEsQSELE | HPRD; phosphoELM | |
| S1097 | YVLSEsQSELE | HPRD | |
| S724 | STDYDsFTFKC | PhosphoSitePlus | |
| T331 | IRLEItSENGE | HPRD | |
| T428 | KSDDGtQDLLH | PhosphoSitePlus; HPRD | |
| T342 | KSDDGtQDLLH | HPRD; phosphoELM | |
| S1088 | YVLSEsQSELE | PhosphoSitePlus | |
| Dephosphorylation site |
| PRD10_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000398431 | *1062W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000302669 | V247M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000432237 | R722Q | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000302669 | R718Q | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000432237 | V247M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000398431 | R722Q | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000398431 | V247M | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| PRD10_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PRD10_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK2_HUMAN | PRD10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK3_HUMAN | PRD10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | PRD10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PRD10_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |