Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MATR3_HUMAN
Description:matrin 3 [Source:HGNC Symbol;Acc:6912]
Location:chr5 q31.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S14SLSRDsQGHGRPhosphoSitePlus; HPRD
T155TEEGPtLSYGRPhosphoSitePlus
T612DKKSKtDGSQKPhosphoSitePlus
S673LLESGsSVGDEPhosphoSitePlus; HPRD; phosphoELM
S62NLGMSsSLNQQHPRD
Y508LPHSGySDSAVPhosphoSitePlus
S654NMLLEsEDELLPhosphoSitePlus; HPRD; phosphoELM
S11QQSSLsRDSQGPhosphoSitePlus
S759PNKDTsENADGHPRD
Y827SSLPHyQKLKKPhosphoSitePlus
Y784YRIGPyQPNVPPhosphoSitePlus
T150LKRRRtEEGPTPhosphoSitePlus
T622KTESStEGKEQPhosphoSitePlus
S621QKTESsTEGKEPhosphoSitePlus
S118ASFGLsARDLDPhosphoSitePlus
Y597SRKRSySPDGKPhosphoSitePlus; HPRD; phosphoELM
S610PSDKKsKTDGSPhosphoSitePlus
S206DYDHGsRSQESPhosphoSitePlus; HPRD; phosphoELM
S157EGPTLsYGRDGPhosphoSitePlus; HPRD
Y773ENKDDyTIPDEPhosphoSitePlus; HPRD
Y214QESGYyDRMDYPhosphoSitePlus; HPRD; phosphoELM
T679SVGDEtDLANLPhosphoSitePlus; HPRD
S195DDRGPsLNPVLPhosphoSitePlus; HPRD; phosphoELM
S533LMRMKsQAFIEPhosphoSitePlus; HPRD; phosphoELM
S22HGRDLsAAGIGPhosphoSitePlus
S748PGAESsENADDPhosphoSitePlus; HPRD
S596KSRKRsYSPDGPhosphoSitePlus; HPRD; phosphoELM
S766NADGQsDENKDPhosphoSitePlus; HPRD; phosphoELM
S208DHGSRsQESGYPhosphoSitePlus; HPRD; phosphoELM
Y202NPVLDyDHGSRPhosphoSitePlus; HPRD
Y250KFDSEyERMGRPhosphoSitePlus
S501RVIHLsNLPHSPhosphoSitePlus
S397GRVETsRVVHIHPRD; phosphoELM
S98GPLPLsSQHRGHPRD
T741KNEENtEPGAEPhosphoSitePlus
T239SFFGEtSHNYHPhosphoSitePlus; HPRD
T811CSLFYtNEEVAPhosphoSitePlus
T618DGSQKtESSTEPhosphoSitePlus
Y219YDRMDyEDDRLPhosphoSitePlus
Y526GKIKNyILMRMPhosphoSitePlus
Y413GKNLRyQLLQLPhosphoSitePlus
S248YHKFDsEYERMPhosphoSitePlus
Y243ETSHNyHKFDSPhosphoSitePlus; HPRD
T49RMNQGtARLASPhosphoSitePlus
S696GKKEPsDKAVKPhosphoSitePlus; phosphoELM
S188HFRRDsFDDRGPhosphoSitePlus; HPRD; phosphoELM
Y520KLAEPyGKIKNPhosphoSitePlus
S620SQKTEsSTEGKPhosphoSitePlus
S674LESGSsVGDETPhosphoSitePlus; HPRD; phosphoELM
S211SRSQEsGYYDRPhosphoSitePlus
Y802PKTGFyCKLCSPhosphoSitePlus
S747EPGAEsSENADPhosphoSitePlus
S598RKRSYsPDGKEPhosphoSitePlus; HPRD; phosphoELM
S77ALSSAsTSSHNPhosphoSitePlus
S606GKESPsDKKSKPhosphoSitePlus; HPRD; phosphoELM
Y171TREPPyRVPRDPhosphoSitePlus; HPRD
S164GRDGRsATREPPhosphoSitePlus; HPRD
S9SFQQSsLSRDSPhosphoSitePlus; HPRD; phosphoELM
T644TKDDQtEQEPNPhosphoSitePlus; HPRD; phosphoELM
Y158GPTLSyGRDGRPhosphoSitePlus; HPRD
S671AALLEsGSSVGPhosphoSitePlus; HPRD; phosphoELM
S54TARLAsLMNLGPhosphoSitePlus
S689LGDVAsDGKKEPhosphoSitePlus; HPRD; phosphoELM
S234RCRDDsFFGETPhosphoSitePlus; HPRD; phosphoELM
S240FFGETsHNYHKPhosphoSitePlus; HPRD
T134PEDKItPENLPPhosphoSitePlus
Y213SQESGyYDRMDPhosphoSitePlus
S4QQSSHPRD
S99PLPLSsQHRGDPhosphoSitePlus
S41LSMPAsLGRMNPhosphoSitePlus; HPRD
S8KSFQQsSLSRDPhosphoSitePlus
Y128DELSRyPEDKIPhosphoSitePlus
T639DGEKDtKDDQTPhosphoSitePlus; HPRD
S604PDGKEsPSDKKPhosphoSitePlus; HPRD; phosphoELM
S615SKTDGsQKTESPhosphoSitePlus
T758DPNKDtSENADHPRD
S4__MSKsFQQSSPhosphoSitePlus

Dephosphorylation site
MATR3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354346R393TBIOMARTBreast Cancer21930507, 21930502
ENSP00000378284R393TBIOMARTBreast Cancer21930507, 21930502
ENSP00000423533R393TBIOMARTBreast Cancer21930507, 21930502
ENSP00000423533S240WTCGAOvarian Cancer21720365, 18772890
ENSP00000354346S240WTCGAOvarian Cancer21720365, 18772890
ENSP00000378284S240WCOSMICOvarian Cancer21720365
ENSP00000378284S240WTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000354346Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.418646787
ENSP00000354346Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
MATR3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANMATR3_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANMATR3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MATR3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0016363nuclear matrixIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005198structural molecule activityTASmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0005637nuclear inner membraneTAScellular_component


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