| UniProt/SwissProt ID: | PRC1_HUMAN |
| Description: | protein regulator of cytokinesis 1 [Source:HGNC Symbol;Acc:9341] |
| Location: | chr15 q26.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T481 | GLAPNtPGKAR | phosphoELM; RegPhos; SysPTM | |
| S592 | SLSDSsTVGLQ | MAP65_ASE1 | PhosphoSitePlus; SysPTM |
| S265 | VATIMsGSKAK | MAP65_ASE1; DUF3700 | PhosphoSitePlus |
| Y560 | ILSGGyPGSAP | HPRD | |
| S587 | FAKDPsLSDSS | HPRD | |
| S591 | PSLSDsSTVGL | MAP65_ASE1 | PhosphoSitePlus |
| T194 | DHTPDtSFERD | HPRD | |
| T616 | GILNStNIQS_ | PhosphoSitePlus | |
| S592 | SLSDSsTVGLQ | HPRD; phosphoELM; RegPhos; SysPTM | |
| T593 | LSDSStVGLQR | MAP65_ASE1 | PhosphoSitePlus |
| Y464 | ETEMLyGSAPR | MAP65_ASE1 | PhosphoSitePlus |
| S472 | APRTPsKRRGL | MAP65_ASE1 | PhosphoSitePlus |
| T481 | GLAPNtPGKAR | CDK2 | HPRD; RegPhos; SysPTM |
| S615 | SGILNsTNI | HPRD | |
| S620 | STNI | HPRD | |
| T536 | CSGKKtPRTGR | HPRD | |
| S554 | LELNGsILSGG | MAP65_ASE1 | PhosphoSitePlus |
| S574 | NFSINsVASTY | MAP65_ASE1 | PhosphoSitePlus |
| T470 | GSAPRtPSKRR | CDK2 | HPRD; RegPhos |
| S195 | HTPDTsFERDV | HPRD; phosphoELM; RegPhos; SysPTM | |
| S589 | KDPSLsDSSTV | HPRD | |
| S466 | EMLYGsAPRTP | MAP65_ASE1 | PhosphoSitePlus |
| S589 | KDPSLsDSSTV | MAP65_ASE1 | PhosphoSitePlus |
| S195 | HTPDTsFERDV | MAP65_ASE1; DUF3700 | PhosphoSitePlus; SysPTM |
| S513 | GTVYHsPVSRL | HPRD; SysPTM | |
| S513 | GTVYHsPVSRL | MAP65_ASE1 | PhosphoSitePlus; SysPTM |
| S577 | INSVAsTYSEF | MAP65_ASE1 | PhosphoSitePlus |
| S265 | VATIMsGSKAK | HPRD | |
| S587 | FAKDPsLSDSS | MAP65_ASE1 | PhosphoSitePlus |
| S615 | SGILNsTNIQS | MAP65_ASE1 | PhosphoSitePlus |
| T191 | EELDHtPDTSF | HPRD; SysPTM | |
| T536 | CSGKKtPRTGR | MAP65_ASE1 | PhosphoSitePlus |
| Y511 | FGGTVyHSPVS | MAP65_ASE1 | PhosphoSitePlus |
| S267 | TIMSGsKAKVR | HPRD | |
| S620 | STNIQs_____ | PhosphoSitePlus | |
| S501 | ATANSsIRPIF | HPRD | |
| T262 | REAVAtIMSGS | MAP65_ASE1; DUF3700 | PhosphoSitePlus |
| S516 | YHSPVsRLPPS | MAP65_ASE1 | PhosphoSitePlus |
| T470 | GSAPRtPSKRR | MAP65_ASE1 | PhosphoSitePlus |
| S571 | LQRNFsINSVA | MAP65_ASE1 | PhosphoSitePlus |
| T379 | DPNRFtNRGGN | MAP65_ASE1 | PhosphoSitePlus |
| T578 | NSVAStYSEFA | MAP65_ASE1 | PhosphoSitePlus |
| T481 | GLAPNtPGKAR | MAP65_ASE1 | PhosphoSitePlus; SysPTM |
| Dephosphorylation site |
| PRC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| PRC1_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000377793 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Down | 0.51 | 16319398 |
| Hyperphosphorylation site |
| PRC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | PRC1_HUMAN | kinase -> substrate | RegPhos |
| CDK2_HUMAN | PRC1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| PRC1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005819 | spindle | IDA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0005876 | spindle microtubule | TAS | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0000910 | cytokinesis | IDA | biological_process |
| GO:0000922 | spindle pole | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008017 | microtubule binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0015630 | microtubule cytoskeleton | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0000910 | cytokinesis | IEA | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0000226 | microtubule cytoskeleton organization | IEA | biological_process |
| GO:0000022 | mitotic spindle elongation | TAS | biological_process |