| UniProt/SwissProt ID: | PPM1B_HUMAN |
| Description: | protein phosphatase, Mg2+/Mn2+ dependent, 1B [Source:HGNC Symbol;Acc:9276] |
| Location: | chr2 p21 |
| Node attribute: | phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S121 | YMRNFsDLRNG | PP2C | PhosphoSitePlus |
| S265 | SRLEVsDDLEN | PP2C | PhosphoSitePlus |
| Y367 | VIEAVySRLNP | PP2C_C | PhosphoSitePlus |
| Dephosphorylation site |
| PPM1B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000282412 | G212D | COSMIC | Renal Cancer | 20054297 | ENSP00000282412 | G203E | COSMIC | Skin Cancer | 21984974 | ENSP00000282412 | E325K | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| PPM1B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PPM1B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PPM1B_HUMAN | IKKB_HUMAN | phosphatase -> substrate | HPRD |
| PPM1B_HUMAN | MOES_HUMAN | phosphatase -> substrate | HPRD |
| PPM1B_HUMAN | CDK2_HUMAN | phosphatase -> substrate | HPRD |
| PPM1B_HUMAN | M3K7_HUMAN | phosphatase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004722 | protein serine/threonine phosphatase activity | IEA | molecular_function |
| GO:0035970 | peptidyl-threonine dephosphorylation | IDA | biological_process |
| GO:0030145 | manganese ion binding | IEA | molecular_function |
| GO:0000287 | magnesium ion binding | IEA | molecular_function |
| GO:0004722 | protein serine/threonine phosphatase activity | IDA | molecular_function |
| GO:0004721 | phosphoprotein phosphatase activity | IEA | molecular_function |
| GO:0006470 | protein dephosphorylation | TAS | biological_process |