Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PPM1B_HUMAN
Description:protein phosphatase, Mg2+/Mn2+ dependent, 1B [Source:HGNC Symbol;Acc:9276]
Location:chr2 p21
Node attribute:phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S121YMRNFsDLRNGPP2CPhosphoSitePlus
S265SRLEVsDDLENPP2CPhosphoSitePlus
Y367VIEAVySRLNPPP2C_CPhosphoSitePlus

Dephosphorylation site
PPM1B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282412G212DCOSMICRenal Cancer20054297
ENSP00000282412G203ECOSMICSkin Cancer21984974
ENSP00000282412E325KCOSMICMelanoma21499247

Differential expressed protein
PPM1B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PPM1B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PPM1B_HUMANIKKB_HUMANphosphatase -> substrateHPRD
PPM1B_HUMANMOES_HUMANphosphatase -> substrateHPRD
PPM1B_HUMANCDK2_HUMANphosphatase -> substrateHPRD
PPM1B_HUMANM3K7_HUMANphosphatase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003824catalytic activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0006470protein dephosphorylationIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004722protein serine/threonine phosphatase activityIEAmolecular_function
GO:0035970peptidyl-threonine dephosphorylationIDAbiological_process
GO:0030145manganese ion bindingIEAmolecular_function
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0004722protein serine/threonine phosphatase activityIDAmolecular_function
GO:0004721phosphoprotein phosphatase activityIEAmolecular_function
GO:0006470protein dephosphorylationTASbiological_process


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