| UniProt/SwissProt ID: | HIRA_HUMAN |
| Description: | HIR histone cell cycle regulation defective homolog A (S. cerevisiae) [Source:HGNC Symbol;Acc:4916] |
| Location: | chr22 q11.21 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T576 | ERSKAtPGAPA | PhosphoSitePlus; HPRD; phosphoELM | |
| S697 | FTLQVsSDPSM | PhosphoSitePlus | |
| Y953 | NEGFEyRLREI | Hira | PhosphoSitePlus |
| T393 | EAQLStAVIEN | PhosphoSitePlus; HPRD | |
| T586 | ALTSMtPTAVE | PhosphoSitePlus; HPRD; phosphoELM | |
| T583 | GAPALtSMTPT | PhosphoSitePlus; HPRD; phosphoELM | |
| T554 | SPSVLtTPSKI | PhosphoSitePlus | |
| S538 | SVNKDsMNATS | HPRD | |
| S650 | RPRKDsRLMPV | PhosphoSitePlus | |
| Y404 | PEMLKyQRRQQ | PhosphoSitePlus | |
| S584 | APALTsMTPTA | PhosphoSitePlus; HPRD; phosphoELM | |
| S661 | SLSVQsPAALT | PhosphoSitePlus; HPRD; phosphoELM | |
| S549 | TPAALsPSVLT | PhosphoSitePlus; HPRD | |
| S557 | VLTTPsKIEPM | PhosphoSitePlus; HPRD | |
| S614 | ESSSDsDEKVP | PhosphoSitePlus; HPRD; phosphoELM | |
| S815 | EESLHsILAGS | Hira | PhosphoSitePlus |
| T555 | PSVLTtPSKIE | CDK2 | HPRD; phosphoELM; RegPhos |
| S687 | KLPIPsPQRAF | CDK2 | HPRD; RegPhos |
| T711 | VENEVtVVGGV | PhosphoSitePlus | |
| S551 | AALSPsVLTTP | HPRD | |
| S687 | KLPIPsPQRAF | PhosphoSitePlus; phosphoELM; RegPhos | |
| T544 | MNATStPAALS | PhosphoSitePlus | |
| T588 | TSMTPtAVERL | PhosphoSitePlus | |
| S812 | VVKEEsLHSIL | Hira | PhosphoSitePlus |
| T555 | PSVLTtPSKIE | PhosphoSitePlus | |
| Y945 | LVYARyLVNEG | Hira | PhosphoSitePlus |
| S610 | RDLLEsSSDSD | PhosphoSitePlus; HPRD; phosphoELM | |
| S611 | DLLESsSDSDE | PhosphoSitePlus; HPRD; phosphoELM | |
| S612 | LLESSsDSDEK | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| HIRA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000345350 | E254* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263208 | M423I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000263208 | E254* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263208 | Q922H | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| HIRA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HIRA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK2_HUMAN | HIRA_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | HIRA_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| HIRA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0016568 | chromatin modification | IEA | biological_process |
| GO:0003714 | transcription corepressor activity | TAS | molecular_function |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0000790 | nuclear chromatin | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0001649 | osteoblast differentiation | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0009653 | anatomical structure morphogenesis | TAS | biological_process |
| GO:0007369 | gastrulation | IEA | biological_process |
| GO:0042692 | muscle cell differentiation | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |