| UniProt/SwissProt ID: | CDC7_HUMAN |
| Description: | cell division cycle 7 [Source:HGNC Symbol;Acc:1745] |
| Location: | chr1 p22.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T376 | APRAGtPGFRA | CDK2 | HPRD |
| T503 | SCLVQtPPGQY | HPRD | |
| S512 | QYSGNsFKKGD | HPRD | |
| S498 | TDHKAsCLVQT | Pkinase | PhosphoSitePlus |
| S16 | EPMAFsPQRDR | PhosphoSitePlus; HPRD | |
| T559 | PASRItAEEAL | Pkinase | PhosphoSitePlus |
| S181 | RDVKPsNFLYN | HPRD | |
| S573 | FFKDMsL____ | PhosphoSitePlus | |
| T376 | APRAGtPGFRA | Pkinase | PhosphoSitePlus |
| Y415 | GRYPFyKASDD | Pkinase | PhosphoSitePlus |
| T503 | SCLVQtPPGQY | Pkinase | PhosphoSitePlus |
| S302 | SISHEsPAVKL | PhosphoSitePlus; HPRD | |
| S556 | DLNPAsRITAE | Pkinase | PhosphoSitePlus |
| S484 | IQGHAsHQPAI | Pkinase | PhosphoSitePlus |
| S509 | PPGQYsGNSFK | Pkinase | PhosphoSitePlus |
| T386 | APEVLtKCPNQ | Pkinase | PhosphoSitePlus |
| T472 | GMDSStPKLTS | Pkinase | PhosphoSitePlus |
| S27 | FQAEGsLKKNE | PhosphoSitePlus; HPRD | |
| S181 | RDVKPsNFLYN | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| CDC7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000234626 | D62G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000234626 | N31fs*51 | COSMIC | Intestines Cancer | ENSP00000234626 | E533Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000393139 | D457H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000234626 | Y48* | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000393139 | D62G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000234626 | D62G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000234626 | G119E | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000393139 | G119E | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000234626 | D457H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000393139 | N31fs*51 | COSMIC | Intestines Cancer | ENSP00000393139 | E533Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000393139 | D62G | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| CDC7_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CDC7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK2_HUMAN | CDC7_HUMAN | kinase -> substrate | HPRD |
| CDC7_HUMAN | MCM7_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04110 | Cell cycle |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0016301 | kinase activity | IDA | molecular_function |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0033261 | regulation of S phase | IMP | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0008284 | positive regulation of cell proliferation | IMP | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000216 | M/G1 transition of mitotic cell cycle | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |