Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDC7_HUMAN
Description:cell division cycle 7 [Source:HGNC Symbol;Acc:1745]
Location:chr1 p22.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T376APRAGtPGFRACDK2HPRD
T503SCLVQtPPGQYHPRD
S512QYSGNsFKKGDHPRD
S498TDHKAsCLVQTPkinasePhosphoSitePlus
S16EPMAFsPQRDRPhosphoSitePlus; HPRD
T559PASRItAEEALPkinasePhosphoSitePlus
S181RDVKPsNFLYNHPRD
S573FFKDMsL____PhosphoSitePlus
T376APRAGtPGFRAPkinasePhosphoSitePlus
Y415GRYPFyKASDDPkinasePhosphoSitePlus
T503SCLVQtPPGQYPkinasePhosphoSitePlus
S302SISHEsPAVKLPhosphoSitePlus; HPRD
S556DLNPAsRITAEPkinasePhosphoSitePlus
S484IQGHAsHQPAIPkinasePhosphoSitePlus
S509PPGQYsGNSFKPkinasePhosphoSitePlus
T386APEVLtKCPNQPkinasePhosphoSitePlus
T472GMDSStPKLTSPkinasePhosphoSitePlus
S27FQAEGsLKKNEPhosphoSitePlus; HPRD
S181RDVKPsNFLYNPkinasePhosphoSitePlus

Dephosphorylation site
CDC7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000234626D62GCOSMICOvarian Cancer21720365
ENSP00000234626N31fs*51COSMICIntestines Cancer
ENSP00000234626E533QCOSMICOvarian Cancer21720365
ENSP00000393139D457HBIOMARTBreast Cancer21930507, 21930502
ENSP00000234626Y48*BIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000393139D62GCOSMICOvarian Cancer21720365
ENSP00000234626D62GTCGAOvarian Cancer21720365, 18772890
ENSP00000234626G119ECOSMICCentral Nervous System Neoplasms18772396
ENSP00000393139G119ECOSMICCentral Nervous System Neoplasms18772396
ENSP00000234626D457HBIOMARTBreast Cancer21930507, 21930502
ENSP00000393139N31fs*51COSMICIntestines Cancer
ENSP00000393139E533QCOSMICOvarian Cancer21720365
ENSP00000393139D62GTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
CDC7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDC7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK2_HUMANCDC7_HUMANkinase -> substrateHPRD
CDC7_HUMANMCM7_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIDAcellular_component
GO:0016301kinase activityIDAmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0006260DNA replicationTASbiological_process
GO:0033261regulation of S phaseIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component


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