Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CABL1_HUMAN
Description:Cdk5 and Abl enzyme substrate 1 [Source:HGNC Symbol;Acc:25097]
Location:chr18 q11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y260PTSQNyCSLEQPhosphoSitePlus
S290LISQRsSLETLPhosphoSitePlus
S311RCRTLsGSPRPPhosphoSitePlus
T309LRRCRtLSGSPPhosphoSitePlus
S418RNTIDsTSSFSPhosphoSitePlus
S313RTLSGsPRPKNCDK3RegPhos; SysPTM
S287RRRLIsQRSSLPhosphoSitePlus
S113STGAVsLKEIIHPRD
T333MRQHDtRNGRIPhosphoSitePlus
S378STGAVsLKEIIPhosphoSitePlus
S432NLSHRsLSIGRPhosphoSitePlus
S46RCRTLsGSPRPHPRD
S108DGGRQsTGAVSHPRD
S262SQNYCsLEQPGPhosphoSitePlus
S313RTLSGsPRPKNCDK2RegPhos; SysPTM
S313RTLSGsPRPKNPhosphoSitePlus; SysPTM
S169SHRSLsIGRASHPRD
S291ISQRSsLETLEPhosphoSitePlus
T244RLNSFtQGILPPhosphoSitePlus
T415GARRNtIDSTSPhosphoSitePlus; phosphoELM; SysPTM
S434SHRSLsIGRASPhosphoSitePlus; SysPTM
T294RSSLEtLEDIEPhosphoSitePlus
S48RTLSGsPRPKNCDK3HPRD
S421IDSTSsFSQFRPhosphoSitePlus
S429QFRNLsHRSLSPhosphoSitePlus
S313RTLSGsPRPKNP24864(Cyclin E1RegPhos; SysPTM
T150GARRNtIDSTSHPRD
T419NTIDStSSFSQPhosphoSitePlus
S25LISQRsSLETLHPRD
S22IRRLIsQRSSLHPRD
T44LRRCRtLSGSPHPRD
S373DGGRQsTGAVSPhosphoSitePlus; SysPTM
S153RNTIDsTSSFSHPRD
S48RTLSGsPRPKNCCNE1HPRD
S242RGRLNsFTQGIPhosphoSitePlus; SysPTM
S257FSRPTsQNYCSPhosphoSitePlus
S168ARGFAsPLGAGPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S26ISQRSsLETLEHPRD

Dephosphorylation site
CABL1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000256925A541TTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000256925P468LCOSMICBreast Cancer20668451

Differential expressed protein
CABL1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CABL1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK3_HUMANCABL1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANCABL1_HUMANkinase -> substrateRegPhos
CDK2_HUMANCABL1_HUMANkinase -> substrateRegPhos
CCNE1_HUMANCABL1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
CABL1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016538cyclin-dependent protein kinase regulator activityIEAmolecular_function
GO:0005829cytosolIDAcellular_component
GO:0051302regulation of cell divisionIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0051726regulation of cell cycleIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0007399nervous system developmentIEAbiological_process


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