| UniProt/SwissProt ID: | CABL1_HUMAN |
| Description: | Cdk5 and Abl enzyme substrate 1 [Source:HGNC Symbol;Acc:25097] |
| Location: | chr18 q11.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y260 | PTSQNyCSLEQ | PhosphoSitePlus | |
| S290 | LISQRsSLETL | PhosphoSitePlus | |
| S311 | RCRTLsGSPRP | PhosphoSitePlus | |
| T309 | LRRCRtLSGSP | PhosphoSitePlus | |
| S418 | RNTIDsTSSFS | PhosphoSitePlus | |
| S313 | RTLSGsPRPKN | CDK3 | RegPhos; SysPTM |
| S287 | RRRLIsQRSSL | PhosphoSitePlus | |
| S113 | STGAVsLKEII | HPRD | |
| T333 | MRQHDtRNGRI | PhosphoSitePlus | |
| S378 | STGAVsLKEII | PhosphoSitePlus | |
| S432 | NLSHRsLSIGR | PhosphoSitePlus | |
| S46 | RCRTLsGSPRP | HPRD | |
| S108 | DGGRQsTGAVS | HPRD | |
| S262 | SQNYCsLEQPG | PhosphoSitePlus | |
| S313 | RTLSGsPRPKN | CDK2 | RegPhos; SysPTM |
| S313 | RTLSGsPRPKN | PhosphoSitePlus; SysPTM | |
| S169 | SHRSLsIGRAS | HPRD | |
| S291 | ISQRSsLETLE | PhosphoSitePlus | |
| T244 | RLNSFtQGILP | PhosphoSitePlus | |
| T415 | GARRNtIDSTS | PhosphoSitePlus; phosphoELM; SysPTM | |
| S434 | SHRSLsIGRAS | PhosphoSitePlus; SysPTM | |
| T294 | RSSLEtLEDIE | PhosphoSitePlus | |
| S48 | RTLSGsPRPKN | CDK3 | HPRD |
| S421 | IDSTSsFSQFR | PhosphoSitePlus | |
| S429 | QFRNLsHRSLS | PhosphoSitePlus | |
| S313 | RTLSGsPRPKN | P24864(Cyclin E1 | RegPhos; SysPTM |
| T150 | GARRNtIDSTS | HPRD | |
| T419 | NTIDStSSFSQ | PhosphoSitePlus | |
| S25 | LISQRsSLETL | HPRD | |
| S22 | IRRLIsQRSSL | HPRD | |
| T44 | LRRCRtLSGSP | HPRD | |
| S373 | DGGRQsTGAVS | PhosphoSitePlus; SysPTM | |
| S153 | RNTIDsTSSFS | HPRD | |
| S48 | RTLSGsPRPKN | CCNE1 | HPRD |
| S242 | RGRLNsFTQGI | PhosphoSitePlus; SysPTM | |
| S257 | FSRPTsQNYCS | PhosphoSitePlus | |
| S168 | ARGFAsPLGAG | PhosphoSitePlus; phosphoELM; RegPhos; SysPTM | |
| S26 | ISQRSsLETLE | HPRD | |
| Dephosphorylation site |
| CABL1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000256925 | A541T | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000256925 | P468L | COSMIC | Breast Cancer | 20668451 |
| Differential expressed protein |
| CABL1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CABL1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK3_HUMAN | CABL1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | CABL1_HUMAN | kinase -> substrate | RegPhos |
| CDK2_HUMAN | CABL1_HUMAN | kinase -> substrate | RegPhos |
| CCNE1_HUMAN | CABL1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| CABL1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016538 | cyclin-dependent protein kinase regulator activity | IEA | molecular_function |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0051302 | regulation of cell division | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0051726 | regulation of cell cycle | IEA | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0007399 | nervous system development | IEA | biological_process |