| UniProt/SwissProt ID: | MYBB_HUMAN |
| Description: | v-myb myeloblastosis viral oncogene homolog (avian)-like 2 [Source:HGNC Symbol;Acc:7548] |
| Location: | chr20 q13.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T444 | LTPKStPVKTL | CDK2 | HPRD; phosphoELM; RegPhos |
| T465 | WNKQDtLELES | PhosphoSitePlus | |
| S393 | ELIPIsPSTEV | CDK2 | HPRD; RegPhos; SysPTM |
| S393 | ELIPIsPSTEV | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S443 | SLTPKsTPVKT | PhosphoSitePlus | |
| T234 | PSVPPtIKEEE | PhosphoSitePlus | |
| S454 | LPFSPsQFLNF | PhosphoSitePlus | |
| S282 | EDQEGsPPETS | PhosphoSitePlus; HPRD; RegPhos | |
| T476 | PSLTStPVCSQ | PhosphoSitePlus | |
| T494 | LHRDKtPLHQK | PhosphoSitePlus | |
| T538 | KPLPQtPHLEE | PhosphoSitePlus | |
| T18 | LHYQDtDSDVP | PhosphoSitePlus | |
| S452 | KTLPFsPSQFL | PhosphoSitePlus | |
| T520 | TPHTPtPFKNA | CDK2 | HPRD; RegPhos |
| T405 | GSGIGtPPSVL | CDK2 | HPRD; RegPhos |
| T487 | KVVVTtPLHRD | PhosphoSitePlus | |
| S472 | ELESPsLTSTP | PhosphoSitePlus | |
| T515 | YSMDNtPHTPT | CDK2 | HPRD; RegPhos |
| S362 | PPRQPsALVPS | PhosphoSitePlus | |
| T518 | DNTPHtPTPFK | CDK2 | HPRD; RegPhos |
| S452 | KTLPFsPSQFL | CDK2 | HPRD; RegPhos |
| S600 | VKLMMsTLPKS | HPRD | |
| T266 | LDAVRtPEPLE | PhosphoSitePlus; phosphoELM; RegPhos; SysPTM | |
| T693 | LKPSHtSRTLI | PhosphoSitePlus | |
| S475 | SPSLTsTPVCS | PhosphoSitePlus | |
| T487 | KVVVTtPLHRD | CDK2 | HPRD; phosphoELM; RegPhos |
| S241 | KEEENsEEELA | PhosphoSitePlus; HPRD | |
| S20 | YQDTDsDVPEQ | PhosphoSitePlus | |
| T405 | GSGIGtPPSVL | PhosphoSitePlus | |
| Y15 | LDELHyQDTDS | PhosphoSitePlus | |
| T440 | SCNSLtPKSTP | CDK2 | HPRD; RegPhos |
| T494 | LHRDKtPLHQK | CDK2 | HPRD; phosphoELM; RegPhos |
| S421 | RRVALsPVTEN | PhosphoSitePlus | |
| T520 | TPHTPtPFKNA | PhosphoSitePlus | |
| S577 | PGLRRsPIKKV | CDK2 | HPRD; phosphoELM; RegPhos |
| T505 | HAAFVtPDQKY | PhosphoSitePlus | |
| S470 | TLELEsPSLTS | PhosphoSitePlus | |
| T266 | LDAVRtPEPLE | CDK2 | HPRD; RegPhos; SysPTM |
| T518 | DNTPHtPTPFK | PhosphoSitePlus | |
| S28 | PEQRDsKCKVK | PhosphoSitePlus | |
| Dephosphorylation site |
| MYBB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000217026 | P131H | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000217026 | L631P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000217026 | R417C | COSMIC | Renal Cancer | 20054297 | ENSP00000217026 | T505I | COSMIC | Skin Cancer | 21984974 | ENSP00000217026 | P394S | COSMIC | Renal Cancer | 21248752 | ENSP00000217026 | L631P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000217026 | G400C | Ding2008, COSMIC | Lung Cancer | 18948947 |
| Differential expressed protein |
| MYBB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MYBB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK2_HUMAN | MYBB_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | MYBB_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05166 | HTLV-I infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0031523 | Myb complex | IEA | cellular_component |
| GO:0090307 | spindle assembly involved in mitosis | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |