| UniProt/SwissProt ID: | NPAT_HUMAN |
| Description: | nuclear protein, ataxia-telangiectasia locus [Source:HGNC Symbol;Acc:7896] |
| Location: | chr11 q22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S227 | LSGPHsTIRNF | PhosphoSitePlus | |
| S535 | SSQLLsQDTSL | PhosphoSitePlus; HPRD; RegPhos | |
| T1270 | LPVPRtPGSGA | CDK2 | RegPhos |
| S1348 | ISRTTsATPLK | PhosphoSitePlus | |
| S1100 | FPNLDsPNVSS | PhosphoSitePlus | |
| T421 | FSQIStSIQKK | PhosphoSitePlus | |
| T770 | GENLPtIILSS | HPRD | |
| S1215 | KQGTSsNNKNV | PhosphoSitePlus | |
| S1214 | KKQGTsSNNKN | PhosphoSitePlus; HPRD | |
| S554 | QFCENsNDTVK | HPRD | |
| T777 | ILSSPtKSPTK | HPRD | |
| S1296 | SSRRFsEDSST | PhosphoSitePlus | |
| S567 | INFHGsKSSDS | PhosphoSitePlus | |
| T113 | SQRARtRTGIA | PhosphoSitePlus; HPRD | |
| S1262 | SRLADsSDLPV | PhosphoSitePlus | |
| T1350 | RTTSAtPLKDN | PhosphoSitePlus | |
| T1140 | ISRHTtIRETQ | PhosphoSitePlus | |
| T1270 | LPVPRtPGSGA | PhosphoSitePlus | |
| S573 | KSSDSsEVHKS | PhosphoSitePlus | |
| T1350 | RTTSAtPLKDN | CDK2 | RegPhos |
| S775 | TIILSsPTKSP | CDK2 | RegPhos |
| S161 | QVTRPsGQISD | HPRD | |
| S219 | ESQRKsTTLSG | PhosphoSitePlus | |
| S165 | PSGQIsDPSRS | HPRD | |
| S779 | SSPTKsPTKNA | CDK2 | RegPhos |
| S1263 | RLADSsDLPVP | PhosphoSitePlus | |
| T115 | RARTRtGIAEI | PhosphoSitePlus; HPRD | |
| T430 | KKAFKtAVPTE | PhosphoSitePlus | |
| S1131 | KILSKsESAIS | PhosphoSitePlus | |
| S775 | TIILSsPTKSP | PhosphoSitePlus; HPRD | |
| T228 | SGPHStIRNFQ | PhosphoSitePlus | |
| T963 | GNNFStPPRQV | PhosphoSitePlus | |
| S204 | KKAHAsLMSPG | HPRD | |
| S774 | PTIILsSPTKS | HPRD | |
| S207 | HASLMsPGRRK | PhosphoSitePlus; HPRD | |
| S1100 | FPNLDsPNVSS | CDK2 | RegPhos |
| S779 | SSPTKsPTKNA | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| NPAT_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000278612 | E704K | COSMIC | Skin Cancer | 21984974 | ENSP00000278612 | Q410E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000278612 | P1046L | COSMIC | Skin Cancer | 21984974 | ENSP00000278612 | Q536* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| NPAT_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NPAT_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | NPAT_HUMAN | kinase -> substrate | RegPhos |
| CDK2_HUMAN | NPAT_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| NPAT_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0015030 | Cajal body | IDA | cellular_component |
| GO:0000083 | regulation of transcription involved in G1/S phase | IMP | biological_process |
| GO:0047485 | protein N-terminus binding | IPI | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0003713 | transcription coactivator activity | IDA | molecular_function |
| GO:0010468 | regulation of gene expression | IMP | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0044428 | nuclear part | IDA | cellular_component |
| GO:0003714 | transcription corepressor activity | IMP | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |