Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:UROK_HUMAN
Description:plasminogen activator, urokinase [Source:HGNC Symbol;Acc:9052]
Location:chr10 q22.2
Node attribute:substrate; ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S323FGKENsTDYLYPKCa(PKC alphaRegPhos
S41GGTCVsNKYFSPhosphoSitePlus
S158DGKKPsSPPEEPKCa(PKC alphaRegPhos
S323FGKENsTDYLYRegPhos
T38CLNGGtCVSNKPhosphoSitePlus
S323FGKENsTDYLYTrypsinPhosphoSitePlus
S158DGKKPsSPPEEPKC_alphaphosphoELM
S158DGKKPsSPPEEPhosphoSitePlus; RegPhos
S323FGKENsTDYLYPKC_alphaphosphoELM

Dephosphorylation site
UROK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361850C91FCOSMICOvarian Cancer21720365
ENSP00000361850P216RCOSMICOvarian Cancer21720365
ENSP00000361850T357ACOSMICRenal Cancer21248752

Differential expressed protein
UROK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
UROK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
UROK_HUMANUPAR_HUMANligand -> receptorHPMR
UROK_HUMANLRP1_HUMANligand -> receptorHPMR
ZAGL2_HUMANUROK_HUMANkinase -> substrateRegPhos
KPCA_HUMANUROK_HUMANkinase -> substrateRobert H Newman (2013)
PKNX1_HUMANUROK_HUMANTF -> target geneTRANSFAC
ETV4_HUMANUROK_HUMANTF -> target geneTRANSFAC
ELF2_HUMANUROK_HUMANTF -> target geneTRANSFAC
JUN_HUMANUROK_HUMANTF -> target geneTRANSFAC
FOS_HUMANUROK_HUMANTF -> target geneTRANSFAC
PBX1_HUMANUROK_HUMANTF -> target geneTRANSFAC
ATF2_HUMANUROK_HUMANTF -> target geneTRANSFAC
JUND_HUMANUROK_HUMANTF -> target geneTRANSFAC
ETS2_HUMANUROK_HUMANTF -> target geneTRANSFAC
PBX2_HUMANUROK_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades
hsa05202Transcriptional misregulation in cancer
hsa04064NF-kappa B signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003824catalytic activityIEAmolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0042730fibrinolysisIEAbiological_process
GO:0061041regulation of wound healingICbiological_process
GO:2000097regulation of smooth muscle cell-matrix adhesionIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042730fibrinolysisTASbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0033628regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006508proteolysisIEAbiological_process
GO:0014909smooth muscle cell migrationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0004252serine-type endopeptidase activityTASmolecular_function
GO:0010469regulation of receptor activityIDAbiological_process
GO:0014910regulation of smooth muscle cell migrationIDAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0005576extracellular regionTAScellular_component
GO:0006935chemotaxisTASbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0007596blood coagulationTASbiological_process


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