| UniProt/SwissProt ID: | UROK_HUMAN |
| Description: | plasminogen activator, urokinase [Source:HGNC Symbol;Acc:9052] |
| Location: | chr10 q22.2 |
| Node attribute: | substrate; ligand; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S323 | FGKENsTDYLY | PKCa(PKC alpha | RegPhos |
| S41 | GGTCVsNKYFS | PhosphoSitePlus | |
| S158 | DGKKPsSPPEE | PKCa(PKC alpha | RegPhos |
| S323 | FGKENsTDYLY | RegPhos | |
| T38 | CLNGGtCVSNK | PhosphoSitePlus | |
| S323 | FGKENsTDYLY | Trypsin | PhosphoSitePlus |
| S158 | DGKKPsSPPEE | PKC_alpha | phosphoELM |
| S158 | DGKKPsSPPEE | PhosphoSitePlus; RegPhos | |
| S323 | FGKENsTDYLY | PKC_alpha | phosphoELM |
| Dephosphorylation site |
| UROK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361850 | C91F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361850 | P216R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361850 | T357A | COSMIC | Renal Cancer | 21248752 |
| Differential expressed protein |
| UROK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| UROK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| UROK_HUMAN | UPAR_HUMAN | ligand -> receptor | HPMR |
| UROK_HUMAN | LRP1_HUMAN | ligand -> receptor | HPMR |
| ZAGL2_HUMAN | UROK_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | UROK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKNX1_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| ETV4_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| ELF2_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| JUN_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| FOS_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| PBX1_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| ATF2_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| JUND_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| ETS2_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| PBX2_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04610 | Complement and coagulation cascades |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa04064 | NF-kappa B signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0009986 | cell surface | IDA | cellular_component |
| GO:0042730 | fibrinolysis | IEA | biological_process |
| GO:0061041 | regulation of wound healing | IC | biological_process |
| GO:2000097 | regulation of smooth muscle cell-matrix adhesion | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042730 | fibrinolysis | TAS | biological_process |
| GO:0042127 | regulation of cell proliferation | IEA | biological_process |
| GO:0033628 | regulation of cell adhesion mediated by integrin | IDA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0014909 | smooth muscle cell migration | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0004252 | serine-type endopeptidase activity | TAS | molecular_function |
| GO:0010469 | regulation of receptor activity | IDA | biological_process |
| GO:0014910 | regulation of smooth muscle cell migration | IDA | biological_process |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0006935 | chemotaxis | TAS | biological_process |
| GO:0001666 | response to hypoxia | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |