| UniProt/SwissProt ID: | ETV4_HUMAN |
| Description: | ets variant 4 [Source:HGNC Symbol;Acc:3493] |
| Location: | chr17 q21.31 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S140 | QIAIKsPAPGA | ETS_PEA3_N | PhosphoSitePlus |
| S149 | GALGQsPLQPF | HPRD; phosphoELM | |
| Y416 | VAGERyVYKFV | Ets | PhosphoSitePlus |
| S140 | QIAIKsPAPGA | HPRD; phosphoELM | |
| Y392 | RPAMNyDKLSR | Ets | PhosphoSitePlus |
| S149 | GALGQsPLQPF | ETS_PEA3_N | PhosphoSitePlus |
| Dephosphorylation site |
| ETV4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377273 | R365Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000377273 | T453R | COSMIC | Ovarian Cancer | 20668451 | ENSP00000321835 | T453R | COSMIC | Ovarian Cancer | 20668451 | ENSP00000321835 | R365Q | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| ETV4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ETV4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ETV4_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| ETV4_HUMAN | FOS_HUMAN | TF -> target gene | TRANSFAC |
| ETV4_HUMAN | MMP3_HUMAN | TF -> target gene | TRANSFAC |
| ETV4_HUMAN | MMP1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ETV4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008045 | motor neuron axon guidance | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0048863 | stem cell differentiation | IEA | biological_process |
| GO:0060444 | branching involved in mammary gland duct morphogen | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0060762 | regulation of branching involved in mammary gland | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0033600 | negative regulation of mammary gland epithelial ce | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |