| UniProt/SwissProt ID: | FLI1_HUMAN |
| Description: | Friend leukemia virus integration 1 [Source:HGNC Symbol;Acc:3749] |
| Location: | chr11 q24.3 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S89 | SVSKCsKLVGG | PhosphoSitePlus; HPRD; phosphoELM | |
| Y332 | KPNMNyDKLSR | Ets | PhosphoSitePlus |
| Y42 | SGSPDyGQPHK | PhosphoSitePlus | |
| S39 | MTASGsPDYGQ | PhosphoSitePlus | |
| S221 | VKEDPsYDSVR | PhosphoSitePlus | |
| Y451 | SHLGSyY____ | PhosphoSitePlus | |
| S76 | DHMNGsRESPV | PhosphoSitePlus; HPRD; phosphoELM | |
| S236 | GNNMNsGLNKS | PhosphoSitePlus | |
| Y452 | HLGSYy_____ | PhosphoSitePlus | |
| S224 | DPSYDsVRRGA | PhosphoSitePlus | |
| S86 | VDCSVsKCSKL | PhosphoSitePlus; HPRD; phosphoELM | |
| S241 | SGLNKsPPLGG | PhosphoSitePlus | |
| S450 | PSHLGsYY___ | PhosphoSitePlus | |
| Y222 | KEDPSyDSVRR | PhosphoSitePlus | |
| Y263 | PQPDPyQILGP | PhosphoSitePlus | |
| T312 | GEFKMtDPDEV | Ets | PhosphoSitePlus |
| Dephosphorylation site |
| FLI1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000399985 | I365T | COSMIC | Lung Cancer | 20668451 | ENSP00000399985 | V410I | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000399985 | G94E | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000399985 | R68W | COSMIC | Lung Cancer | 20668451 | ENSP00000399985 | H394R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| FLI1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| T312 | Ets | TNGEFKMtDPDEVAR | scleroderma | 21321929 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FLI1_HUMAN | EGR1_HUMAN | TF -> target gene | TRANSFAC |
| FLI1_HUMAN | FOS_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| FLI1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009887 | organ morphogenesis | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000980 | RNA polymerase II distal enhancer sequence-specifi | IEA | molecular_function |
| GO:0008015 | blood circulation | IEA | biological_process |
| GO:0007599 | hemostasis | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |