| UniProt/SwissProt ID: | HBB_HUMAN |
| Description: | hemoglobin, beta [Source:HGNC Symbol;Acc:4827] |
| Location: | chr11 p15.4 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S45 | QRFFEsFGDLS | Globin | PhosphoSitePlus |
| T51 | FGDLStPDAVM | Globin | PhosphoSitePlus |
| Y146 | ALAHKyH____ | PhosphoSitePlus | |
| S50 | SFGDLsTPDAV | HPRD | |
| Y131 | PVQAAyQKVVA | Globin | PhosphoSitePlus |
| Y131 | PVQAAyQKVVA | HPRD; phosphoELM | |
| T5 | EEKS | HPRD | |
| T124 | FGKEFtPPVQA | Globin | PhosphoSitePlus |
| S10 | TPEEKsAVTAL | HPRD | |
| T39 | VVYPWtQRFFE | Globin | PhosphoSitePlus |
| Y36 | RLLVVyPWTQR | Globin | PhosphoSitePlus |
| S73 | VLGAFsDGLAH | HPRD | |
| S10 | TPEEKsAVTAL | Globin | PhosphoSitePlus |
| S73 | VLGAFsDGLAH | Globin | PhosphoSitePlus |
| S50 | SFGDLsTPDAV | Globin | PhosphoSitePlus |
| T5 | _MVHLtPEEKS | PhosphoSitePlus | |
| S45 | QRFFEsFGDLS | HPRD | |
| Dephosphorylation site |
| HBB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000333994 | G57A | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000333994 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 4.3 | 14726492 | ENSP00000333994 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000333994 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.29 | 17627933 | ENSP00000333994 | Breast Cancer | Normal vs. Cancer | tissue | Up | 1.3 | 16550499 | ENSP00000333994 | Breast Cancer | Normal vs. Cancer | tissue | Up | 1.4 | 16550499 | ENSP00000333994 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 6 | 18401453 | ENSP00000333994 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 6.8 | 18401453 | ENSP00000333994 | Hepatocellular Carcinoma | Cancer vs. Cancer (HCC vs. HuCCA) | cell line | Up | 20069059 | ENSP00000333994 | Neoplasms by Histologic Type | Normal vs. Cancer | tissue | Down | 0.25 | 12874873 | ENSP00000333994 | Lung Cancer | Normal vs. Cancer | tissue | Down | 15626334 | ENSP00000333994 | Breast Cancer | Normal vs. Cancer | cell line | Up | 2.9 | 20052998 | ENSP00000333994 | Breast Cancer | Normal vs. Cancer | cell line | Up | 2.4 | 20052998 | ENSP00000333994 | Breast Cancer | Metastasis | cell line | Down | 0.87 | 20052998 | ENSP00000333994 | Oral Cancer | Normal vs. Cancer | tissue | Down | 0.5 | 19691830 | ENSP00000333994 | chronic lymphocytic leukemia | Cancer vs. Cancer (agressive) | tissue | Down | 0.3 | 16083281 | ENSP00000333994 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.41 | 19610612 | ENSP00000333994 | Uterine Cancer | Treatment (Concurrent chemoradiotherapy-lowly vs. Concurrent chemoradiotherapy-highly sensitive) | tissue | Up | 19507834 | ENSP00000333994 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 3.3 | 16739137 |
| Hyperphosphorylation site |
| HBB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FOS_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| Q15552_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| KLF1_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| NF2L2_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| KLF4_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| KLF11_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| GATA1_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| MAFG_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| JUN_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| NF2L1_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| TFCP2_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| HBB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0010942 | positive regulation of cell death | IDA | biological_process |
| GO:0015701 | bicarbonate transport | TAS | biological_process |
| GO:0045429 | positive regulation of nitric oxide biosynthetic p | NAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0020037 | heme binding | IEA | molecular_function |
| GO:0042744 | hydrogen peroxide catabolic process | IDA | biological_process |
| GO:0031720 | haptoglobin binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004601 | peroxidase activity | IDA | molecular_function |
| GO:0030492 | hemoglobin binding | IDA | molecular_function |
| GO:0019825 | oxygen binding | IEA | molecular_function |
| GO:0015671 | oxygen transport | NAS | biological_process |
| GO:0070293 | renal absorption | IMP | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0042542 | response to hydrogen peroxide | IDA | biological_process |
| GO:0008217 | regulation of blood pressure | IEA | biological_process |
| GO:0031838 | haptoglobin-hemoglobin complex | IDA | cellular_component |
| GO:0005506 | iron ion binding | IEA | molecular_function |
| GO:0005344 | oxygen transporter activity | IEA | molecular_function |
| GO:0051291 | protein heterooligomerization | IDA | biological_process |
| GO:0050880 | regulation of blood vessel size | IEA | biological_process |
| GO:0030185 | nitric oxide transport | NAS | biological_process |
| GO:0005833 | hemoglobin complex | IEA | cellular_component |