Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCL3_HUMAN
Description:chemokine (C-C motif) ligand 3 [Source:HGNC Symbol;Acc:10627]
Location:chr17 q12
Node attribute:ligand; PPI(target)

Phosphorylation site
CCL3_HUMAN do not have phosphorylation site.

Dephosphorylation site
CCL3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000225245T53SBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CCL3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCL3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCL3_HUMANCCR5_HUMANligand -> receptorHPMR
CCL3_HUMANCCR1_HUMANligand -> receptorHPMR
NFKB1_HUMANCCL3_HUMANotherKEGG
IRF5_HUMANCCL3_HUMANotherKEGG
FOS_HUMANCCL3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04620Toll-like receptor signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa05132Salmonella infection
hsa05142Chagas disease (American trypanosomiasis)
hsa05323Rheumatoid arthritis
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004698calcium-dependent protein kinase C activityIDAmolecular_function
GO:0010629negative regulation of gene expressionIDAbiological_process
GO:0043615astrocyte cell migrationISSbiological_process
GO:0048246macrophage chemotaxisISSbiological_process
GO:0070723response to cholesterolIDAbiological_process
GO:0016310phosphorylationIDAbiological_process
GO:0042056chemoattractant activityIDAmolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0010818T cell chemotaxisIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0043922negative regulation by host of viral transcriptionIDAbiological_process
GO:0000165MAPK cascadeIEPbiological_process
GO:0071346cellular response to interferon-gammaIEPbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0001775cell activationIDAbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:2000503positive regulation of natural killer cell chemotaIDAbiological_process
GO:0006874cellular calcium ion homeostasisIDAbiological_process
GO:0071347cellular response to interleukin-1IEPbiological_process
GO:0016301kinase activityIDAmolecular_function
GO:0019722calcium-mediated signalingIDAbiological_process
GO:0050850positive regulation of calcium-mediated signalingIMPbiological_process
GO:0014808release of sequestered calcium ion into cytosol byIDAbiological_process
GO:0071621granulocyte chemotaxisIDAbiological_process
GO:0043491protein kinase B signaling cascadeIMPbiological_process
GO:0048245eosinophil chemotaxisIDAbiological_process
GO:0005622intracellularIDAcellular_component
GO:0030593neutrophil chemotaxisIDAbiological_process
GO:0050918positive chemotaxisIDAbiological_process
GO:0051928positive regulation of calcium ion transportIDAbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0045671negative regulation of osteoclast differentiationIDAbiological_process
GO:0071407cellular response to organic cyclic compoundIDAbiological_process
GO:0051897positive regulation of protein kinase B signaling IEPbiological_process
GO:0007610behaviorIDAbiological_process
GO:0007267cell-cell signalingIDAbiological_process
GO:0051930regulation of sensory perception of painIDAbiological_process
GO:0050718positive regulation of interleukin-1 beta secretioISSbiological_process
GO:0043525positive regulation of neuron apoptotic processISSbiological_process
GO:0043308eosinophil degranulationIDAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0032760positive regulation of tumor necrosis factor produISSbiological_process
GO:0031726CCR1 chemokine receptor bindingIPImolecular_function
GO:0007010cytoskeleton organizationIDAbiological_process
GO:0006887exocytosisIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0030502negative regulation of bone mineralizationIDAbiological_process
GO:0071356cellular response to tumor necrosis factorIEPbiological_process
GO:0008360regulation of cell shapeIDAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0016004phospholipase activator activityIDAmolecular_function
GO:0023052signalingIEPbiological_process
GO:0009636response to toxinIDAbiological_process
GO:0031730CCR5 chemokine receptor bindingIPImolecular_function
GO:0006816calcium ion transportIDAbiological_process
GO:0008009chemokine activityIDAmolecular_function
GO:0001649osteoblast differentiationIEPbiological_process
GO:0006954inflammatory responseIDAbiological_process
GO:0006935chemotaxisIDAbiological_process
GO:0006955immune responseIEAbiological_process
GO:0002548monocyte chemotaxisICbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0005576extracellular regionIDAcellular_component
GO:0048247lymphocyte chemotaxisIDAbiological_process
GO:0050729positive regulation of inflammatory responseISSbiological_process