Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DRA_HUMAN
Description:major histocompatibility complex, class II, DR alpha [Source:HGNC Symbol;Acc:4947]
Location:chrHSCHR6_MHC_COX p2
Node attribute:gene

Phosphorylation site
DRA_HUMAN do not have phosphorylation site.

Dephosphorylation site
DRA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378786M98ICOSMICOvarian Cancer21720365
ENSP00000378786E113KCOSMICMelanoma21499247
ENSP00000378786E216*COSMICHead and Neck Cancer21798893
ENSP00000378786E197DCOSMICSkin Cancer21984974
ENSP00000378786G150RBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000372746Oral CancerNormal vs. CancertissueUp519297561
ENSP00000372746Breast CancerMetastasiscell lineUp>519321434
ENSP00000372746Breast CancerNormal vs. Cancercell lineDown0.1820198662

Hyperphosphorylation site
DRA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
XBP1_HUMANDRA_HUMANTF -> target geneTRANSFAC
RFX2_HUMANDRA_HUMANTF -> target geneTRANSFAC
RFX4_HUMANDRA_HUMANTF -> target geneTRANSFAC
RFX3_HUMANDRA_HUMANTF -> target geneTRANSFAC
FOS_HUMANDRA_HUMANTF -> target geneTRANSFAC
CREB1_HUMANDRA_HUMANTF -> target geneTRANSFAC
RFX1_HUMANDRA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
DRA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0031295T cell costimulationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030658transport vesicle membraneTAScellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0006955immune responseIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0019882antigen processing and presentationIEAbiological_process
GO:0005887integral to plasma membraneNAScellular_component
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0006955immune responseNASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0002504antigen processing and presentation of peptide or IEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0030669clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0000139Golgi membraneTAScellular_component
GO:0032395MHC class II receptor activityNASmolecular_function
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0032588trans-Golgi network membraneTAScellular_component
GO:0005764lysosomeIDAcellular_component
GO:0042613MHC class II protein complexIEAcellular_component
GO:0071556integral to lumenal side of endoplasmic reticulum TAScellular_component
GO:0031902late endosome membraneIDAcellular_component
GO:0019886antigen processing and presentation of exogenous pTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0005765lysosomal membraneIDAcellular_component


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