Phosphorylation

Source	Target	Relationship	Resource
EDN1_HUMAN	EDNRA_HUMAN	ligand -> receptor	HPMR
FOS_HUMAN	EDN1_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	EDN1_HUMAN	TF -> target gene	TRANSFAC
GATA2_HUMAN	EDN1_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa04916	Melanogenesis

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0005615	extracellular space	IEA	cellular_component
GO:0030818	negative regulation of cAMP biosynthetic process	IEA	biological_process
GO:0043406	positive regulation of MAP kinase activity	IDA	biological_process
GO:0042554	superoxide anion generation	IEA	biological_process
GO:0032269	negative regulation of cellular protein metabolic	IDA	biological_process
GO:0035815	positive regulation of renal sodium excretion	IEA	biological_process
GO:0060137	maternal process involved in parturition	IEA	biological_process
GO:0006885	regulation of pH	IEA	biological_process
GO:0046888	negative regulation of hormone secretion	IEA	biological_process
GO:0007589	body fluid secretion	IEA	biological_process
GO:0070101	positive regulation of chemokine-mediated signalin	IC	biological_process
GO:0071356	cellular response to tumor necrosis factor	IEA	biological_process
GO:0005737	cytoplasm	IDA	cellular_component
GO:0007205	protein kinase C-activating G-protein coupled rece	IEA	biological_process
GO:0045321	leukocyte activation	TAS	biological_process
GO:0001821	histamine secretion	IEA	biological_process
GO:0031708	endothelin B receptor binding	IEA	molecular_function
GO:0005125	cytokine activity	IDA	molecular_function
GO:0030185	nitric oxide transport	IDA	biological_process
GO:0007204	elevation of cytosolic calcium ion concentration	IEA	biological_process
GO:0034392	negative regulation of smooth muscle cell apoptoti	IEA	biological_process
GO:0090023	positive regulation of neutrophil chemotaxis	IEA	biological_process
GO:0051771	negative regulation of nitric-oxide synthase biosy	IDA	biological_process
GO:0035810	positive regulation of urine volume	IEA	biological_process
GO:0001569	patterning of blood vessels	IEA	biological_process
GO:0014826	vein smooth muscle contraction	IDA	biological_process
GO:0008284	positive regulation of cell proliferation	IEA	biological_process
GO:0019233	sensory perception of pain	IEA	biological_process
GO:0035094	response to nicotine	IEA	biological_process
GO:0010870	positive regulation of receptor biosynthetic proce	IDA	biological_process
GO:0005576	extracellular region	TAS	cellular_component
GO:0032496	response to lipopolysaccharide	IEA	biological_process
GO:0014065	phosphatidylinositol 3-kinase cascade	IDA	biological_process
GO:0042474	middle ear morphogenesis	IEA	biological_process
GO:0048016	inositol phosphate-mediated signaling	IDA	biological_process
GO:0042482	positive regulation of odontogenesis	IEA	biological_process
GO:0005179	hormone activity	IDA	molecular_function
GO:0042310	vasoconstriction	IEA	biological_process
GO:0043179	rhythmic excitation	IEA	biological_process
GO:0003100	regulation of systemic arterial blood pressure by	IDA	biological_process
GO:0030195	negative regulation of blood coagulation	TAS	biological_process
GO:0051930	regulation of sensory perception of pain	IEA	biological_process
GO:0010259	multicellular organismal aging	IEA	biological_process
GO:0001516	prostaglandin biosynthetic process	IDA	biological_process
GO:0008217	regulation of blood pressure	IEA	biological_process
GO:0031707	endothelin A receptor binding	IEA	molecular_function
GO:0005515	protein binding	IEA	molecular_function
GO:0046887	positive regulation of hormone secretion	IDA	biological_process
GO:0031708	endothelin B receptor binding	IDA	molecular_function
GO:0010595	positive regulation of endothelial cell migration	TAS	biological_process
GO:0015758	glucose transport	IEA	biological_process
GO:0045793	positive regulation of cell size	IDA	biological_process
GO:0042045	epithelial fluid transport	IEA	biological_process
GO:0051899	membrane depolarization	IEA	biological_process
GO:0010460	positive regulation of heart rate	IDA	biological_process
GO:0051216	cartilage development	IEA	biological_process
GO:0007243	intracellular protein kinase cascade	IEA	biological_process
GO:0033574	response to testosterone stimulus	IEA	biological_process
GO:0007166	cell surface receptor signaling pathway	IDA	biological_process
GO:0019722	calcium-mediated signaling	IDA	biological_process
GO:0030335	positive regulation of cell migration	IDA	biological_process
GO:0048514	blood vessel morphogenesis	IEA	biological_process
GO:0019229	regulation of vasoconstriction	IEA	biological_process
GO:0001666	response to hypoxia	IEA	biological_process
GO:0001701	in utero embryonic development	IEA	biological_process
GO:0045429	positive regulation of nitric oxide biosynthetic p	TAS	biological_process
GO:0060585	positive regulation of prostaglandin-endoperoxide	IMP	biological_process
GO:0048661	positive regulation of smooth muscle cell prolifer	IDA	biological_process
GO:0042310	vasoconstriction	IDA	biological_process
GO:0007267	cell-cell signaling	IDA	biological_process
GO:0051482	elevation of cytosolic calcium ion concentration i	IEA	biological_process
GO:0043200	response to amino acid stimulus	IEA	biological_process
GO:0007186	G-protein coupled receptor signaling pathway	IDA	biological_process
GO:0007204	elevation of cytosolic calcium ion concentration	IDA	biological_process
GO:0008284	positive regulation of cell proliferation	IDA	biological_process
GO:0005102	receptor binding	IEA	molecular_function
GO:0060298	positive regulation of sarcomere organization	IMP	biological_process
GO:0042313	protein kinase C deactivation	IDA	biological_process
GO:0014824	artery smooth muscle contraction	TAS	biological_process
GO:0000122	negative regulation of transcription from RNA poly	IDA	biological_process
GO:0007507	heart development	IEA	biological_process
GO:0007585	respiratory gaseous exchange	IEA	biological_process
GO:0042493	response to drug	IEA	biological_process
GO:0043507	positive regulation of JUN kinase activity	IDA	biological_process
GO:0031583	phospholipase D-activating G-protein coupled recep	IEA	biological_process
GO:0031707	endothelin A receptor binding	IDA	molecular_function
GO:0045840	positive regulation of mitosis	IDA	biological_process
GO:0010613	positive regulation of cardiac muscle hypertrophy	IDA	biological_process
GO:0045987	positive regulation of smooth muscle contraction	IEA	biological_process
GO:0001501	skeletal system development	IEA	biological_process
GO:0005615	extracellular space	IDA	cellular_component
GO:0071347	cellular response to interleukin-1	IEA	biological_process
GO:0014032	neural crest cell development	IEA	biological_process
GO:0009953	dorsal/ventral pattern formation	IEA	biological_process
GO:0030072	peptide hormone secretion	IDA	biological_process
GO:0016049	cell growth	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network