Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MMP1_HUMAN
Description:matrix metallopeptidase 1 (interstitial collagenase) [Source:HGNC Symbol;Acc:7155]
Location:chr11 q22.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S280PKACDsKLTFDHPRD
Y360NVLHGyPKDIYHemopexinPhosphoSitePlus
S153TFTKVsEGQADPeptidase_M10PhosphoSitePlus
Y360NVLHGyPKDIYHPRD
T289FDAITtIRGEVHPRD
T288TFDAItTIRGEHPRD

Dephosphorylation site
MMP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000322788L181ICOSMICHead and Neck Cancer21798893
ENSP00000322788E313QCOSMICOvarian Cancer21720365
ENSP00000322788V312IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000322788E39KCOSMICSkin Cancer21984974
ENSP00000322788A330SBIOMARTBreast Cancer21930507, 21930502
ENSP00000322788T274ICOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000322788Breast CancerNormal vs. Cancercell lineDown0.05419053080

Hyperphosphorylation site
MMP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ETV5_HUMANMMP1_HUMANTF -> target geneTRANSFAC
SMAD4_HUMANMMP1_HUMANTF -> target geneTRANSFAC
JUN_HUMANMMP1_HUMANTF -> target geneTRANSFAC
FOS_HUMANMMP1_HUMANTF -> target geneTRANSFAC
SMAD3_HUMANMMP1_HUMANTF -> target geneTRANSFAC
ETS1_HUMANMMP1_HUMANTF -> target geneTRANSFAC
ETV4_HUMANMMP1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
MMP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007596blood coagulationTASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0022617extracellular matrix disassemblyTASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0030198extracellular matrix organizationTASbiological_process
GO:0004222metalloendopeptidase activityIDAmolecular_function
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0031012extracellular matrixIEAcellular_component
GO:0006508proteolysisIEAbiological_process
GO:0030574collagen catabolic processIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0008237metallopeptidase activityIEAmolecular_function


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