Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL6_HUMAN
Description:interleukin 6 (interferon, beta 2) [Source:HGNC Symbol;Acc:6018]
Location:chr7 p15.3
Node attribute:PPI(target); ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S135QNRFEsSEEQAIL6PhosphoSitePlus
T165NLDAItTPDPTIL6PhosphoSitePlus
S136NRFESsEEQARIL6PhosphoSitePlus
S81NMCESsKEALAHPRD

Dephosphorylation site
IL6_HUMAN do not have dephosphorylation site.

Mutation site
IL6_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000258743Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.5415169874
ENSP00000258743Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.415169874

Hyperphosphorylation site
IL6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IL6_HUMANIL6RB_HUMANligand -> receptorHPMR
NFKB1_HUMANIL6_HUMANotherKEGG
FOS_HUMANIL6_HUMANotherKEGG
IRF5_HUMANIL6_HUMANotherKEGG
CEBPB_HUMANIL6_HUMANTF -> target geneTRANSFAC
SUH_HUMANIL6_HUMANTF -> target geneTRANSFAC
GCR_HUMANIL6_HUMANTF -> target geneTRANSFAC
TF65_HUMANIL6_HUMANTF -> target geneTRANSFAC
CEBPD_HUMANIL6_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05152Tuberculosis
hsa04640Hematopoietic cell lineage
hsa04672Intestinal immune network for IgA production
hsa05144Malaria
hsa05162Measles
hsa05133Pertussis
hsa05146Amoebiasis
hsa05202Transcriptional misregulation in cancer
hsa05132Salmonella infection
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05020Prion diseases
hsa04060Cytokine-cytokine receptor interaction
hsa04620Toll-like receptor signaling pathway
hsa05200Pathways in cancer
hsa05142Chagas disease (American trypanosomiasis)
hsa05166HTLV-I infection
hsa04623Cytosolic DNA-sensing pathway
hsa04630Jak-STAT signaling pathway
hsa05134Legionellosis
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05323Rheumatoid arthritis
hsa05332Graft-versus-host disease
hsa04621NOD-like receptor signaling pathway
hsa05143African trypanosomiasis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006953acute-phase responseTASbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0042517positive regulation of tyrosine phosphorylation ofIEAbiological_process
GO:0045188regulation of circadian sleep/wake cycle, non-REM IEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:1901215negative regulation of neuron deathIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0043154negative regulation of cysteine-type endopeptidaseIEAbiological_process
GO:0051384response to glucocorticoid stimulusIDAbiological_process
GO:0002675positive regulation of acute inflammatory responseIDAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0032966negative regulation of collagen biosynthetic proceIDAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIDAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0045765regulation of angiogenesisICbiological_process
GO:0045630positive regulation of T-helper 2 cell differentiaIEAbiological_process
GO:0045079negative regulation of chemokine biosynthetic procIEAbiological_process
GO:0060445branching involved in salivary gland morphogenesisIEAbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0050871positive regulation of B cell activationIDAbiological_process
GO:2000366positive regulation of STAT protein import into nuICbiological_process
GO:0033160positive regulation of protein import into nucleusIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0042832defense response to protozoanIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0006954inflammatory responseIDAbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007568agingIEAbiological_process
GO:0002446neutrophil mediated immunityICbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0060664epithelial cell proliferation involved in salivaryIEAbiological_process
GO:0005138interleukin-6 receptor bindingIEAmolecular_function
GO:0010574regulation of vascular endothelial growth factor pIDAbiological_process
GO:0005896interleukin-6 receptor complexIDAcellular_component
GO:0046677response to antibioticIEAbiological_process
GO:0002548monocyte chemotaxisICbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pIEAbiological_process
GO:0031667response to nutrient levelsIEAbiological_process
GO:0045727positive regulation of translationIDAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0046716muscle cell homeostasisIEAbiological_process
GO:0006469negative regulation of protein kinase activityIEAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0046427positive regulation of JAK-STAT cascadeIEAbiological_process
GO:0016049cell growthIEAbiological_process
GO:0006959humoral immune responseICbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0050710negative regulation of cytokine secretionIEAbiological_process
GO:0002384hepatic immune responseTASbiological_process
GO:0008083growth factor activityIDAmolecular_function
GO:0042981regulation of apoptotic processIDAbiological_process
GO:0046427positive regulation of JAK-STAT cascadeIDAbiological_process
GO:0009617response to bacteriumIEAbiological_process
GO:0051971positive regulation of transmission of nerve impulIEAbiological_process
GO:0010888negative regulation of lipid storageNASbiological_process
GO:0045599negative regulation of fat cell differentiationNASbiological_process
GO:0070102interleukin-6-mediated signaling pathwayIEAbiological_process
GO:0031000response to caffeineIEAbiological_process
GO:0031175neuron projection developmentIMPbiological_process
GO:0009409response to coldIEAbiological_process
GO:0051602response to electrical stimulusIEAbiological_process
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0042110T cell activationIEAbiological_process
GO:0045740positive regulation of DNA replicationIEAbiological_process
GO:0046849bone remodelingIEAbiological_process
GO:0002690positive regulation of leukocyte chemotaxisICbiological_process
GO:0006955immune responseIEAbiological_process
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0032755positive regulation of interleukin-6 productionIDAbiological_process
GO:0032722positive regulation of chemokine productionIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0045721negative regulation of gluconeogenesisIEAbiological_process
GO:0050829defense response to Gram-negative bacteriumIEPbiological_process
GO:0048635negative regulation of muscle organ developmentIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0019221cytokine-mediated signaling pathwayIDAbiological_process
GO:0001781neutrophil apoptotic processIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0031018endocrine pancreas developmentIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0009408response to heatIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0070091glucagon secretionIEAbiological_process
GO:0009611response to woundingIEAbiological_process
GO:0046888negative regulation of hormone secretionIEAbiological_process
GO:0042102positive regulation of T cell proliferationIDAbiological_process
GO:0045669positive regulation of osteoblast differentiationTASbiological_process
GO:0051607defense response to virusIDAbiological_process
GO:0050830defense response to Gram-positive bacteriumIEPbiological_process
GO:0051024positive regulation of immunoglobulin secretionIDAbiological_process
GO:0032494response to peptidoglycanIEPbiological_process
GO:0070301cellular response to hydrogen peroxideIDAbiological_process
GO:0051592response to calcium ionIEAbiological_process
GO:0045454cell redox homeostasisIEAbiological_process