Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRIO_HUMAN
Description:prion protein [Source:HGNC Symbol;Acc:9449]
Location:chr20 p13
Node attribute:substrate

Phosphorylation site
PRIO_HUMAN do not have phosphorylation site.

Dephosphorylation site
PRIO_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368752M129VCOSMICSkin Cancer21984974
ENSP00000399376M129VTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000368752M129VTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000415284Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
PRIO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TYRO3_HUMANPRIO_HUMANkinase -> substrateRobert H Newman (2013)
SG494_HUMANPRIO_HUMANkinase -> substrateRobert H Newman (2013)
FAK1_HUMANPRIO_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PRIO_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051087chaperone bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0032703negative regulation of interleukin-2 productionISSbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0005783endoplasmic reticulumISScellular_component
GO:0070885negative regulation of calcineurin-NFAT signaling ISSbiological_process
GO:0008152metabolic processTASbiological_process
GO:0001933negative regulation of protein phosphorylationISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005794Golgi apparatusISScellular_component
GO:0007050cell cycle arrestIEAbiological_process
GO:0015631tubulin bindingIDAmolecular_function
GO:0070885negative regulation of calcineurin-NFAT signaling IEAbiological_process
GO:0046686response to cadmium ionIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0032700negative regulation of interleukin-17 productionISSbiological_process
GO:0006878cellular copper ion homeostasisNASbiological_process
GO:0019898extrinsic to membraneTAScellular_component
GO:0006979response to oxidative stressISSbiological_process
GO:0016020membraneIEAcellular_component
GO:0046007negative regulation of activated T cell proliferatIEAbiological_process
GO:0050860negative regulation of T cell receptor signaling pIEAbiological_process
GO:0045121membrane raftISScellular_component
GO:0031225anchored to membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0043433negative regulation of sequence-specific DNA bindiIEAbiological_process
GO:0005886plasma membraneISScellular_component
GO:0007411axon guidanceTASbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0032703negative regulation of interleukin-2 productionIEAbiological_process
GO:0005507copper ion bindingIDAmolecular_function
GO:0001933negative regulation of protein phosphorylationIEAbiological_process
GO:0046688response to copper ionIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0005730nucleolusIDAcellular_component
GO:0032689negative regulation of interferon-gamma productionIEAbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0008017microtubule bindingIDAmolecular_function
GO:0032689negative regulation of interferon-gamma productionISSbiological_process
GO:0050860negative regulation of T cell receptor signaling pISSbiological_process
GO:0043008ATP-dependent protein bindingIEAmolecular_function
GO:0051260protein homooligomerizationIEAbiological_process
GO:0032700negative regulation of interleukin-17 productionIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0046007negative regulation of activated T cell proliferatISSbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0043433negative regulation of sequence-specific DNA bindiISSbiological_process


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