Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ROCK1_HUMAN
Description:Rho-associated, coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:10251]
Location:chr18 q11.1
Node attribute:PPI(target); substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S282PFYADsLVGTYPkinase_AGCPhosphoSitePlus
T1180HVRPVtQGDVYHPRD; phosphoELM
T1331RASPRtLSTRSPhosphoSitePlus
S1102LSDSTsVASFPPhosphoSitePlus; HPRD; phosphoELM
T897LDLAEtKAESEMyosin_tail_1PhosphoSitePlus
Y604TDKDYyQLQAIMyosin_tail_1; Myosin_taiPhosphoSitePlus
Y255GGDGYyGRECDPkinase_AGCPhosphoSitePlus
T917QYFELtQESKKPhosphoSitePlus
T455EQKCRtSNIKLHPRD
S1100LDLSDsTSVASPhosphoSitePlus; HPRD; phosphoELM
S572SHTEMsKSISQMyosin_tail_1; Myosin_taiPhosphoSitePlus
T398PFVGFtYYSNRPkinase_CPhosphoSitePlus
S1328GFVRAsPRTLSPhosphoSitePlus
T1180HVRPVtQGDVYPHPhosphoSitePlus
S456QKCRTsNIKLDHPRD
Y405YSNRRyLSSANPhosphoSitePlus
T569LRKSHtEMSKSMyosin_tail_1; Myosin_taiPhosphoSitePlus
S1098KLLDLsDSTSVHPRD; phosphoELM
T1337LSTRStANQSFPhosphoSitePlus
S574TEMSKsISQLEMyosin_tail_1; Myosin_taiPhosphoSitePlus
S1336TLSTRsTANQSPhosphoSitePlus
S1108VASFPsADETDPhosphoSitePlus
S1333SPRTLsTRSTAPhosphoSitePlus
Y1153KKILFyNDEQDPHPhosphoSitePlus
T1101DLSDStSVASFPhosphoSitePlus; HPRD; phosphoELM
T1189VYRAEtEEIPKPHPhosphoSitePlus
T1024RKKANtQDLRKPhosphoSitePlus
T1334PRTLStRSTANPhosphoSitePlus
S456QKCRTsNIKLDMyosin_tail_1PhosphoSitePlus
T887QNEKEtLATQLMyosin_tail_1PhosphoSitePlus
S710IEEAKsVAMCEMyosin_tail_1PhosphoSitePlus
Y913LLEEQyFELTQPhosphoSitePlus
S567VRLRKsHTEMSMyosin_tail_1; Myosin_taiPhosphoSitePlus
T455EQKCRtSNIKLMyosin_tail_1PhosphoSitePlus
S1341STANQsFRKVVPhosphoSitePlus
Y603QTDKDyYQLQAMyosin_tail_1; Myosin_taiPhosphoSitePlus
T890KETLAtQLDLAMyosin_tail_1PhosphoSitePlus
Y1287PCKVSyDVTSAPhosphoSitePlus
S576MSKSIsQLESLMyosin_tail_1; Myosin_taiPhosphoSitePlus
S407NRRYLsSANPNPhosphoSitePlus
S1105STSVAsFPSADPhosphoSitePlus; HPRD
S533KVSQNsQLANEMyosin_tail_1; HR1; MyosiPhosphoSitePlus

Dephosphorylation site
ROCK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000382697P1193SGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000382697S263LBIOMARTBreast Cancer21930507, 21930502
ENSP00000382697K721QBIOMARTBreast Cancer21930507, 21930502
ENSP00000382697D364GDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000382697S1126*Greenman2007Breast Cancer15908952, 17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000382697Uterine CancerNormal vs. CancertissueDown0.09819007971

Hyperphosphorylation site
ROCK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ROCK1_HUMANMYPT1_HUMANkinase -> substrateRegPhos
ROCK1_HUMANDPYL2_HUMANkinase -> substrateHPRD; RegPhos
ROCK1_HUMANSL9A1_HUMANkinase -> substrateKEGG
ROCK1_HUMANDESM_HUMANkinase -> substrateRegPhos
ROCK1_HUMANFYV1_HUMANkinase -> substrateKEGG
ROCK1_HUMANFAK1_HUMANkinase -> substrateRegPhos
MK01_HUMANROCK1_HUMANkinase -> substrateKEGG
ROCK1_HUMANPTEN_HUMANkinase -> substrateRegPhos
ROCK1_HUMANML12B_HUMANkinase -> substrateRegPhos
ROCK1_HUMANEZRI_HUMANkinase -> substrateHPRD; RegPhos
ROCK1_HUMANARHG7_HUMANkinase -> substrateKEGG
ROCK1_HUMANLIMK2_HUMANkinase -> substrateRegPhos
ROCK1_HUMANVASP_HUMANkinase -> substrateRegPhos
ROCK1_HUMANADDA_HUMANkinase -> substrateRegPhos
ROCK1_HUMANRADI_HUMANkinase -> substrateRegPhos
ROCK1_HUMANMOES_HUMANkinase -> substrateHPRD; RegPhos
ROCK1_HUMANMYLK_HUMANkinase -> substrateKEGG
ROCK1_HUMANGFAP_HUMANkinase -> substrateRegPhos
ROCK1_HUMANLIMK1_HUMANkinase -> substrateKEGG; HPRD; RegPhos
ROCK1_HUMANRHG24_HUMANkinase -> substrateRegPhos
ROCK1_HUMANVIME_HUMANkinase -> substrateHPRD; RegPhos
RHOA_HUMANROCK1_HUMANotherKEGG
ROCK1_HUMANML12B_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04350TGF-beta signaling pathway
hsa04360Axon guidance
hsa05131Shigellosis
hsa05130Pathogenic Escherichia coli infection
hsa05132Salmonella infection
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04310Wnt signaling pathway
hsa04270Vascular smooth muscle contraction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0022614membrane to membrane dockingIDAbiological_process
GO:0007159leukocyte cell-cell adhesionIDAbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0050901leukocyte tethering or rollingIDAbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0000910cytokinesisIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0032060bleb assemblyIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:2000145regulation of cell motilityTASbiological_process
GO:0032059blebIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0051893regulation of focal adhesion assemblyTASbiological_process
GO:0032970regulation of actin filament-based processIEAbiological_process
GO:0007266Rho protein signal transductionTASbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0005814centrioleIEAcellular_component
GO:0032956regulation of actin cytoskeleton organizationTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0051492regulation of stress fiber assemblyTASbiological_process
GO:2000114regulation of establishment of cell polarityTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0006939smooth muscle contractionTASbiological_process
GO:0016525negative regulation of angiogenesisIMPbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0030155regulation of cell adhesionTASbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0017048Rho GTPase bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0050900leukocyte migrationIDAbiological_process
GO:0003383apical constrictionIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0045616regulation of keratinocyte differentiationIMPbiological_process
GO:0005543phospholipid bindingIEAmolecular_function


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