Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACTN1_HUMAN
Description:actinin, alpha 1 [Source:HGNC Symbol;Acc:163]
Location:chr14 q24.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S832DQVMAsFKILAefhand_Ca_insenPhosphoSitePlus
Y246YVSSFyHAFSGCHPhosphoSitePlus
Y12QQTNDyMQPEEPTK2HPRD
S6MDHYDsQQTNDPhosphoSitePlus
Y674SHLRQyEKSIVSpectrin; XisIPhosphoSitePlus
S140AIQDIsVEETSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y4__MDHyDSQQTPhosphoSitePlus
Y842AGDKNyITMDEefhand_Ca_insenPhosphoSitePlus
Y582KIVQTyHVNMASpectrinPhosphoSitePlus
T737ENQILtRDAKGEF_hand_5PhosphoSitePlus
Y681KSIVNyKPKIDSpectrin; XisIPhosphoSitePlus
S243IMTYVsSFYHACHPhosphoSitePlus
S250FYHAFsGAQKACHPhosphoSitePlus
Y193PELIDyGKLRKHPRD; phosphoELM
Y467NELDYyDSPSVSpectrinPhosphoSitePlus
T123GNVKMtLGMIWCHPhosphoSitePlus
Y859PDQAEyCIARMefhand_Ca_insenPhosphoSitePlus
T50LRKAGtQIENIHPRD; phosphoELM; RegPhos
Y193PELIDyGKLRKCHPhosphoSitePlus
Y215DVAEKyLDIPKCHPhosphoSitePlus
Y708NKHTNyTMEHISpectrin; XisIPhosphoSitePlus
Y12QQTNDyMQPEEPhosphoSitePlus
Y241KAIMTyVSSFYCHPhosphoSitePlus
T50LRKAGtQIENICHPhosphoSitePlus
Y12QQTNDyMQPEEFAKphosphoELM; RegPhos
S73LLEVIsGERLACHPhosphoSitePlus
T9YDSQQtNDYMQPhosphoSitePlus
S669LEDQLsHLRQYSpectrin; XisIPhosphoSitePlus
S244MTYVSsFYHAFCHPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y12DSQQTNDyMQPEEDWPTPN1HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000193403S145LCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000193403Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.818646787
ENSP00000193403Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000193403Oral CancerNormal vs. CancertissueUp419297561
ENSP00000193403MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.3717854218
ENSP00000193403Breast CancerNormal vs. CancertissueUp18257521
ENSP00000193403Hepatocellular CarcinomaMetastasiscell lineUp1.519016532
ENSP00000193403Gastric CancerNormal vs. CancertissueDown0.4815761955
ENSP00000193403Pancreatic CancerNormal vs. CancertissueUp2.819199705

Hyperphosphorylation site
ACTN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FAK1_HUMANACTN1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANACTN1_HUMANkinase -> substrateRegPhos
PTN1_HUMANACTN1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05322Systemic lupus erythematosus
hsa04520Adherens junction
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04530Tight junction
hsa05146Amoebiasis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002576platelet degranulationTASbiological_process
GO:0043197dendritic spineIEAcellular_component
GO:0042995cell projectionIDAcellular_component
GO:0031143pseudopodiumTAScellular_component
GO:0051017actin filament bundle assemblyIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0017166vinculin bindingIPImolecular_function
GO:0030018Z discIEAcellular_component
GO:0001726ruffleIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0048041focal adhesion assemblyIMPbiological_process
GO:0005925focal adhesionIMPcellular_component
GO:0005856cytoskeletonIEAcellular_component
GO:0003779actin bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0005916fascia adherensIEAcellular_component
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0044325ion channel bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005178integrin bindingIDAmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0042981regulation of apoptotic processNASbiological_process
GO:0051015actin filament bindingIEAmolecular_function
GO:0051764actin crosslink formationIEAbiological_process
GO:0051271negative regulation of cellular component movementIMPbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0034329cell junction assemblyTASbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function


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