| UniProt/SwissProt ID: | TRIO_HUMAN |
| Description: | trio Rho guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:12303] |
| Location: | chr5 p15.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S297 | FPKKNsGSGNA | Spectrin | PhosphoSitePlus |
| T1545 | SELGVtEHVEG | PH | PhosphoSitePlus |
| S2440 | KDARAsLGTLP | HPRD | |
| S2417 | MKVLEsPRKGA | PhosphoSitePlus; HPRD | |
| S2208 | KKKGFsMPGFL | PH | PhosphoSitePlus |
| S2462 | LNSPLsSAVPS | HPRD | |
| S2391 | GPSAPsRRPPG | PhosphoSitePlus | |
| S2388 | PEAGPsAPSRR | PhosphoSitePlus | |
| S2467 | SSAVPsLGKEP | HPRD | |
| S2459 | ASPLNsPLSSA | PhosphoSitePlus; HPRD | |
| T1899 | LLVRPtSSETP | PhosphoSitePlus | |
| S1785 | PVRRLsSGKAD | PhosphoSitePlus | |
| S2282 | LNALTsPIEYQ | PhosphoSitePlus; HPRD | |
| S2495 | PASPAsRPGSF | PhosphoSitePlus | |
| S1459 | LEVMLsVPKRA | RhoGEF | PhosphoSitePlus |
| T1903 | PTSSEtPSAAE | PhosphoSitePlus; HPRD | |
| T2513 | SLQRQtPRHAA | PhosphoSitePlus | |
| T1844 | PTSSEtPSAAE | phosphoELM; RegPhos | |
| Y1228 | AVDKRyRDFSL | Spectrin | PhosphoSitePlus |
| T1824 | DDSAAtPQDET | PhosphoSitePlus | |
| T724 | TTLQVtVNVIK | Spectrin | PhosphoSitePlus |
| S1900 | LVRPTsSETPS | PhosphoSitePlus | |
| Y2796 | NFDSFySEVAE | PhosphoSitePlus | |
| Y2058 | RRLHMyIAYCQ | RhoGEF | PhosphoSitePlus |
| S1779 | RKWLTsPVRRL | PhosphoSitePlus; HPRD | |
| S116 | LACIPsEEVCK | CRAL_TRIO | PhosphoSitePlus |
| T2625 | ENPDGtLKKST | PhosphoSitePlus | |
| S299 | KKNSGsGNADL | Spectrin | PhosphoSitePlus |
| Y2737 | NFDSFySEVAE | FAK | RegPhos |
| Y2796 | NFDSFySEVAE | PTK2 | HPRD |
| Y2286 | TSPIEyQRNHS | PhosphoSitePlus | |
| Y2737 | NFDSFySEVAE | phosphoELM; RegPhos | |
| S2455 | RAGAAsPLNSP | PhosphoSitePlus; HPRD | |
| S1809 | REVRKsADAGS | PhosphoSitePlus | |
| S2492 | SSIPAsPASRP | PhosphoSitePlus | |
| Y2659 | KLENGyRKSRE | PhosphoSitePlus | |
| T1778 | LRKWLtSPVRR | PhosphoSitePlus | |
| T1486 | SELGVtEHVEG | phosphoELM; RegPhos | |
| Y2075 | HIVSEyIDTFF | RhoGEF | PhosphoSitePlus |
| S1901 | VRPTSsETPSA | PhosphoSitePlus | |
| S1847 | GTLSKsSSSGM | PhosphoSitePlus | |
| S1854 | SSGMQsCGEEE | PhosphoSitePlus | |
| S2429 | NASGSsPDAPA | PhosphoSitePlus; HPRD | |
| S2508 | PGDSDsLQRQT | PhosphoSitePlus | |
| S1786 | VRRLSsGKADG | PhosphoSitePlus | |
| S1814 | SADAGsQKDSD | PhosphoSitePlus | |
| T2281 | FLNALtSPIEY | HPRD | |
| Dephosphorylation site |
| TRIO_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339299 | G2854fs*16 | COSMIC | Intestines Cancer | ENSP00000339299 | L364V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339299 | T1317M | COSMIC | Melanoma | ENSP00000339299 | D658N | COSMIC | Skin Cancer | 21984974 | ENSP00000339299 | N1671K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000339299 | G53E | COSMIC | Melanoma | ENSP00000339299 | D2995N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339291 | N167S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339299 | N2668S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339299 | R1078G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000339299 | P2378L | COSMIC | Skin Cancer | 21984974 | ENSP00000339299 | A3042V | COSMIC | Intestines Cancer | ENSP00000339299 | N1121K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000339299 | D2176E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000339299 | V698M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000339299 | I1576V | COSMIC | Gastric Cancer | 21097718 | ENSP00000339291 | D494N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339299 | G2575E | COSMIC | Melanoma | ENSP00000339299 | R2876C | COSMIC | Breast Cancer | 15908952 | ENSP00000339299 | N3003S | COSMIC | Renal Cancer | 20054297 | ENSP00000339299 | V1978M | COSMIC | Melanoma | ENSP00000339299 | M1129I | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| TRIO_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TRIO_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | TRIO_HUMAN | kinase -> substrate | RegPhos |
| FAK1_HUMAN | TRIO_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| TRIO_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005085 | guanyl-nucleotide exchange factor activity | TAS | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatas | TAS | biological_process |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | biological_process |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |