| UniProt/SwissProt ID: | STYK1_HUMAN |
| Description: | serine/threonine/tyrosine kinase 1 [Source:HGNC Symbol;Acc:18889] |
| Location: | chr12 p13.2 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S59 | TQQQRsGPQGI | PhosphoSitePlus | |
| S91 | PLKETsVENFL | PhosphoSitePlus | |
| Y221 | MDGLLyDLTEK | Pkinase_Tyr | PhosphoSitePlus |
| T224 | LLYDLtEKQVY | Pkinase_Tyr | PhosphoSitePlus |
| T90 | LPLKEtSVENF | PhosphoSitePlus | |
| Dephosphorylation site |
| STYK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000075503 | V395I | Greenman2007, HPI | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 | ENSP00000075503 | Y417C | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000075503 | L316F | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000075503 | V395I | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 |
| Differential expressed protein |
| STYK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| STYK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| STYK1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STYK1_HUMAN | SRC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STYK1_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STYK1_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STYK1_HUMAN | FRK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STYK1_HUMAN | ABI2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STYK1_HUMAN | GNA12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STYK1_HUMAN | MLX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STYK1_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| STYK1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004715 | non-membrane spanning protein tyrosine kinase acti | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |