| UniProt/SwissProt ID: | DYRK4_HUMAN |
| Description: | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:HGNC Symbol;Acc:3095] |
| Location: | chr12 p13.32 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T457 | TKDSPtKHVQH | PhosphoSitePlus | |
| T211 | IVRRFtLSVLK | Pkinase | PhosphoSitePlus |
| S213 | RRFTLsVLKCL | Pkinase | PhosphoSitePlus |
| T263 | HQKVYtYIQSR | Pkinase | PhosphoSitePlus |
| Y262 | EHQKVyTYIQS | Pkinase | PhosphoSitePlus |
| Y264 | QKVYTyIQSRF | Pkinase | PhosphoSitePlus |
| Y264 | QKVYTyIQSRF | phosphoELM | |
| Y356 | RGKKRyPDSKD | Pkinase | PhosphoSitePlus |
| T37 | QKVTLtAAEAL | PhosphoSitePlus | |
| T445 | KADEItKETTE | PhosphoSitePlus | |
| S437 | QGCHHsSRKAD | PhosphoSitePlus | |
| S267 | YTYIQsRFYRS | Pkinase | PhosphoSitePlus |
| S222 | CLQMLsVEKII | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| DYRK4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000010132 | L221F | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000010132 | G252R | BIOMART | Brain Cancer | 21930507, 21930502 |
| Differential expressed protein |
| DYRK4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DYRK4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DYRK4_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | SRA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | ERF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | NPM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | NRIP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | RNH1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | CBL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | PHAX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | C2D1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | PRS6A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | DGCR8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | MK12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | RUVB1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | CCM2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | CHIP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | SPN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | CHSP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | 4ET_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | NUDT3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | STIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | CSDE1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | NANO1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | NADAP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | MLX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | GCFC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | SMAD4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | BMX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | SRSF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | TRI26_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | EXOS3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | IF4H_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | UHMK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | RD23B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | SRC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | SAFB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | 1433F_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | IRF3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | LRRF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | HCLS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | KAPCB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | SART3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | AGGF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | SRXN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | IF4A3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | ABI2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | ZYX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | DDX4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | TIA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | KKCC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| DYRK4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | NAS | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | NAS | molecular_function |
| GO:0005524 | ATP binding | NAS | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0016301 | kinase activity | IEA | molecular_function |