Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DGCR8_HUMAN
Description:DiGeorge syndrome critical region gene 8 [Source:HGNC Symbol;Acc:2847]
Location:chr22 q11.21
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S271KYGGDsDHPSDPhosphoSitePlus; HPRD; phosphoELM
Y267RTEEKyGGDSDPhosphoSitePlus; HPRD; phosphoELM
S8TDESPsPLPCGPhosphoSitePlus
T371QSSDLtPSGDVPhosphoSitePlus
S92IDPNCsGHSPRPhosphoSitePlus; HPRD; phosphoELM
S377PSGDVsPVKPLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S545EPFGAsVTIDGdsrm; PEGAPhosphoSitePlus
S95NCSGHsPRTARPhosphoSitePlus; HPRD; phosphoELM
S383PVKPLsRSAELHPRD; SysPTM
S109AVRKFsPDLKLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T547FGASVtIDGVTdsrm; PEGAPhosphoSitePlus
S280SDGETsVQPMMPhosphoSitePlus
S373SDLTPsGDVSPPhosphoSitePlus; HPRD
T279PSDGEtSVQPMHPRD; phosphoELM
S275DSDHPsDGETSPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
DGCR8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263209E214KBIOMARTBreast Cancer21930507, 21930502
ENSP00000384726E141QBIOMARTBreast Cancer21930507, 21930502
ENSP00000372488E141QBIOMARTBreast Cancer21930507, 21930502
ENSP00000263209E141QBIOMARTBreast Cancer21930507, 21930502
ENSP00000372488E214KBIOMARTBreast Cancer21930507, 21930502
ENSP00000372488E47QBIOMARTBreast Cancer21930507, 21930502
ENSP00000384726E47QBIOMARTBreast Cancer21930507, 21930502
ENSP00000384726E214KBIOMARTBreast Cancer21930507, 21930502
ENSP00000263209E47QBIOMARTBreast Cancer21930507, 21930502
ENSP00000263209S44GCOSMICHead and Neck Cancer21798893

Differential expressed protein
DGCR8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DGCR8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDKL5_HUMANDGCR8_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANDGCR8_HUMANkinase -> substrateRobert H Newman (2013)
NTKL_HUMANDGCR8_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANDGCR8_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DGCR8_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046872metal ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0003725double-stranded RNA bindingIDAmolecular_function
GO:0031053primary miRNA processingIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0010467gene expressionTASbiological_process


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