| UniProt/SwissProt ID: | TIA1_HUMAN |
| Description: | TIA1 cytotoxic granule-associated RNA binding protein [Source:HGNC Symbol;Acc:11802] |
| Location: | chr2 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T99 | STVVStQRSQD | PhosphoSitePlus | |
| Y149 | GKSKGyGFVSF | RRM_1 | PhosphoSitePlus |
| S199 | VVNQSsPSNCT | HPRD | |
| S210 | VVNQSsPSNCT | PhosphoSitePlus; HPRD; phosphoELM | |
| S198 | EVVNQsSPSNC | HPRD | |
| S209 | EVVNQsSPSNC | PhosphoSitePlus; HPRD; phosphoELM | |
| Y48 | AGNDPyCFVEF | RRM_1 | PhosphoSitePlus |
| Dephosphorylation site |
| TIA1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| TIA1_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000401371 | hepatitis B virus | Normal vs. Cancer | tissue | Down | 0.36 | 14726492 |
| Hyperphosphorylation site |
| TIA1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FASTK_HUMAN | TIA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | TIA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | TIA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TIA1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0008143 | poly(A) RNA binding | TAS | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0017091 | AU-rich element binding | IEA | molecular_function |
| GO:0010494 | cytoplasmic stress granule | IEA | cellular_component |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0006917 | induction of apoptosis | TAS | biological_process |
| GO:0048024 | regulation of mRNA splicing, via spliceosome | IDA | biological_process |
| GO:0017148 | negative regulation of translation | IEA | biological_process |
| GO:0042036 | negative regulation of cytokine biosynthetic proce | IEA | biological_process |
| GO:0006915 | apoptotic process | IEA | biological_process |