Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TIA1_HUMAN
Description:TIA1 cytotoxic granule-associated RNA binding protein [Source:HGNC Symbol;Acc:11802]
Location:chr2 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T99STVVStQRSQDPhosphoSitePlus
Y149GKSKGyGFVSFRRM_1PhosphoSitePlus
S199VVNQSsPSNCTHPRD
S210VVNQSsPSNCTPhosphoSitePlus; HPRD; phosphoELM
S198EVVNQsSPSNCHPRD
S209EVVNQsSPSNCPhosphoSitePlus; HPRD; phosphoELM
Y48AGNDPyCFVEFRRM_1PhosphoSitePlus

Dephosphorylation site
TIA1_HUMAN do not have dephosphorylation site.

Mutation site
TIA1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000401371hepatitis B virusNormal vs. CancertissueDown0.3614726492

Hyperphosphorylation site
TIA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FASTK_HUMANTIA1_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANTIA1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANTIA1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TIA1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0008143poly(A) RNA bindingTASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0017091AU-rich element bindingIEAmolecular_function
GO:0010494cytoplasmic stress granuleIEAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0006917induction of apoptosisTASbiological_process
GO:0048024regulation of mRNA splicing, via spliceosomeIDAbiological_process
GO:0017148negative regulation of translationIEAbiological_process
GO:0042036negative regulation of cytokine biosynthetic proceIEAbiological_process
GO:0006915apoptotic processIEAbiological_process


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